SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice

por Schwartzkopf, Chad D, Liu, Guang, Hadcock, John R, Currie, Mark G, Masferrer, Jamie L, Jones, Juli E
Publicado 2020

Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

por Schwartzkopf, Chad D., Hadcock, John R., Liu, Guang, Germano, Peter, Roux, Julien, Shea, Courtney M., Buys, Emmanuel S., Jones, Juli E.
Publicado 2022

5-HT(2C)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

por Xu, Yong, Jones, Juli E., Kohno, Daisuke, Williams, Kevin W., Lee, Charlotte E., Choi, Michelle J., Anderson, Jason G., Heisler, Lora K., Zigman, Jeffrey M., Lowell, Bradford B., Elmquist, Joel K.
Publicado 2008

5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver

por Xu, Yong, Berglund, Eric D., Sohn, Jong-Woo, Holland, William L., Chuang, Jen-Chieh, Fukuda, Makoto, Rossi, Jari, Williams, Kevin W., Jones, Juli E., Zigman, Jeffrey M., Lowell, Bradford B., Scherer, Philipp E., Elmquist, Joel K.
Publicado 2010

Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease

por Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.
Publicado 2021

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

por Correia, Susana S., Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G., Tobin, Jenny V., Schwartzkopf, Chad D., Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R., Currie, Mark G., Hadcock, John R., Winrow, Christopher J., Jones, Juli E.
Publicado 2021

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

por Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Publicado 2021

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

por Zimmer, Daniel P., Shea, Courtney M., Tobin, Jenny V., Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R., Jacobson, Sarah, Bernier, Sylvie G., Sarno, Renee, Carvalho, Andrew, Chien, Yueh-tyng, Graul, Regina, Buys, Emmanuel S., Jones, Juli E., Wakefield, James D., Price, Gavrielle M., Chickering, Jennifer G., Milne, G. Todd, Currie, Mark G., Masferrer, Jaime L.
Publicado 2020