Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

por Struik, Dicky, Dommerholt, Marleen B., Jonker, Johan W.
Publicado 2019

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

por Aaldijk, Alexandra S., Verzijl, Cristy R. C., Jonker, Johan W., Struik, Dicky
Publicado 2023

The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease

por Grefhorst, Aldo, van de Peppel, Ivo P., Larsen, Lars E., Jonker, Johan W., Holleboom, Adriaan G.
Publicado 2021

Senescent cells in the development of cardiometabolic disease

por Postmus, Andrea C., Sturmlechner, Ines, Jonker, Johan W., van Deursen, Jan M., van de Sluis, Bart, Kruit, Janine K.
Publicado 2019

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

por Lamia, Katja A., Papp, Stephanie J., Yu, Ruth T., Barish, Grant D., Uhlenhaut, N. Henriette, Jonker, Johan W., Downes, Michael, Evans, Ronald M.
Publicado 2011

Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR

por Zwarts, Irene, van Zutphen, Tim, Kruit, Janine K., Liu, Weilin, Oosterveer, Maaike H., Verkade, Henkjan J., Uhlenhaut, N. Henriette, Jonker, Johan W.
Publicado 2019

Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes

por Saeed, Ali, Bartuzi, Paulina, Heegsma, Janette, Dekker, Daphne, Kloosterhuis, Niels, de Bruin, Alain, Jonker, Johan W., van de Sluis, Bart, Faber, Klaas Nico
Publicado 2020

Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice

por Boesjes, Marije, Bloks, Vincent W., Hageman, Jurre, Bos, Trijnie, van Dijk, Theo H., Havinga, Rick, Wolters, Henk, Jonker, Johan W., Kuipers, Folkert, Groen, Albert K.
Publicado 2014

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice

por Ikpa, Pauline T., Doktorova, Marcela, Meijsen, Kelly F., Nieuwenhuijze, Natascha D.A., Verkade, Henkjan J., Jonker, Johan W., de Jonge, Hugo R., Bijvelds, Marcel J.C.
Publicado 2019

Fibroblast Growth Factor Signaling in Metabolic Regulation

por Nies, Vera J. M., Sancar, Gencer, Liu, Weilin, van Zutphen, Tim, Struik, Dicky, Yu, Ruth T., Atkins, Annette R., Evans, Ronald M., Jonker, Johan W., Downes, Michael Robert
Publicado 2016

Autocrine FGF1 signaling promotes glucose uptake in adipocytes

por Nies, Vera J. M., Struik, Dicky, Liu, Sihao, Liu, Weilin, Kruit, Janine K., Downes, Michael, van Zutphen, Tim, Verkade, Henkjan J., Evans, Ronald M., Jonker, Johan W.
Publicado 2022

The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition

por van de Peppel, Ivo P., Rao, Anuradha, Dommerholt, Marleen B., Bongiovanni, Laura, Thomas, Rachel, de Bruin, Alain, Karpen, Saul J., Dawson, Paul A., Verkade, Henkjan J., Jonker, Johan W.
Publicado 2020

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

por Doktorova, Marcela, Zwarts, Irene, Zutphen, Tim van, Dijk, Theo H. van, Bloks, Vincent W., Harkema, Liesbeth, Bruin, Alain de, Downes, Michael, Evans, Ronald M., Verkade, Henkjan J., Jonker, Johan W.
Publicado 2017

Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer’s Disease?

por Martens, Nikita, Zhan, Na, Voortman, Gardi, Leijten, Frank P. J., van Rheenen, Connor, van Leerdam, Suzanne, Geng, Xicheng, Huybrechts, Michiel, Liu, Hongbing, Jonker, Johan W., Kuipers, Folkert, Lütjohann, Dieter, Vanmierlo, Tim, Mulder, Monique T.
Publicado 2023

24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease

por Martens, Nikita, Schepers, Melissa, Zhan, Na, Leijten, Frank, Voortman, Gardi, Tiane, Assia, Rombaut, Ben, Poisquet, Janne, van de Sande, Nienke, Kerksiek, Anja, Kuipers, Folkert, Jonker, Johan W., Liu, Hongbing, Lütjohann, Dieter, Vanmierlo, Tim, Mulder, Monique T.
Publicado 2021

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

por Dommerholt, Marleen B., Blankestijn, Maaike, Vieira‐Lara, Marcel A., van Dijk, Theo H., Wolters, Henk, Koster, Mirjam H., Gerding, Albert, van Os, Ronald P., Bloks, Vincent W., Bakker, Barbara M., Kruit, Janine K., Jonker, Johan W.
Publicado 2020

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

por Jonker, Johan W., Suh, Jae Myoung, Atkins, Annette R., Ahmadian, Maryam, Li, Pingping, Whyte, Jamie, He, Mingxiao, Juguilon, Henry, Yin, Yun-Qiang, Phillips, Colin T., Yu, Ruth T., Olefsky, Jerrold M., Henry, Robert R., Downes, Michael, Evans, Ronald M.
Publicado 2012

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/−) mice

por Huerta Guevara, Ana P., McGowan, Sara J., Kazantzis, Melissa, Stallons, Tania Rozgaja, Sano, Tokio, Mulder, Niels L., Jurdzinski, Angelika, van Dijk, Theo H., Eggen, Bart J.L., Jonker, Johan W., Niedernhofer, Laura J., Kruit, Janine K.
Publicado 2021

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism

por Blankestijn, Maaike, Bloks, Vincent W., Struik, Dicky, Huijkman, Nicolette, Kloosterhuis, Niels, Wolters, Justina C., Wanders, Ronald J. A., Vaz, Frédéric M., Islinger, Markus, Kuipers, Folkert, van de Sluis, Bart, Groen, Albert K., Verkade, Henkjan J., Jonker, Johan W.
Publicado 2022

Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction

por Arvidsson Kvissberg, Matilda E., Hu, Guanlan, Chi, Lijun, Bourdon, Celine, Ling, Cino, ChenMi, YueYing, Germain, Kyla, van Peppel, Ivo P., Weise, Linnea, Zhang, Ling, Di Giovanni, Valeria, Swain, Nathan, Jonker, Johan W., Kim, Peter, Bandsma, Robert
Publicado 2022