Molecularly profiled trials: toward a framework of actions for the “nil actionables”

por Jordan, Allan Michael
Publicado 2021

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

por Ortíz, Cecilia, Moraca, Francesca, Laverriere, Marc, Jordan, Allan, Hamilton, Niall, Comini, Marcelo A.
Publicado 2021

Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

por Piper, Jordan Allan, Jansen, Margo Iris, Thomas Broome, Sarah, Rodgers, Kenneth J., Musumeci, Giuseppe, Castorina, Alessandro
Publicado 2022

Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

por Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R., Lichawska-Cieslar, Agata, Jordan, Allan M., Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni
Publicado 2014

L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid

por Piper, Jordan Allan, Al Hammouri, Nour, Jansen, Margo Iris, Rodgers, Kenneth J., Musumeci, Giuseppe, Dhungana, Amolika, Ghorbanpour, Sahar Masoumeh, Bradfield, Laura A., Castorina, Alessandro
Publicado 2023

Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5)

por Pearson, Adam J., Fullwood, Paul, Toro Tapia, Gabriela, Prise, Ian, Smith, Michael P., Xu, Qiuping, Jordan, Allan, Giurisato, Emanuele, Whitmarsh, Alan J., Francavilla, Chiara, Tournier, Cathy
Publicado 2020

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade

por Watson, Amanda J., Hopkins, Gemma V., Hitchin, Samantha, Begum, Habiba, Jones, Stuart, Jordan, Allan, Holt, Sarah, March, H. Nikki, Newton, Rebecca, Small, Helen, Stowell, Alex, Waddell, Ian D., Waszkowycz, Bohdan, Ogilvie, Donald J.
Publicado 2016

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure

por Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.
Publicado 2019

Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

por Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado 2016

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

por Pillay, Nisha, Tighe, Anthony, Nelson, Louisa, Littler, Samantha, Coulson-Gilmer, Camilla, Bah, Nourdine, Golder, Anya, Bakker, Bjorn, Spierings, Diana C.J., James, Dominic I., Smith, Kate M., Jordan, Allan M., Morgan, Robert D., Ogilvie, Donald J., Foijer, Floris, Jackson, Dean A., Taylor, Stephen S.
Publicado 2019

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

por Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W., Oliver, Antony W.
Publicado 2016

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

por Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Publicado 2018

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

por Murray, James B., Davidson, James, Chen, Ijen, Davis, Ben, Dokurno, Pawel, Graham, Christopher J., Harris, Richard, Jordan, Allan, Matassova, Natalia, Pedder, Christopher, Ray, Stuart, Roughley, Stephen D., Smith, Julia, Walmsley, Claire, Wang, Yikang, Whitehead, Neil, Williamson, Douglas S., Casara, Patrick, Le Diguarher, Thierry, Hickman, John, Stark, Jerome, Kotschy, András, Geneste, Olivier, Hubbard, Roderick E.
Publicado 2019

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

por Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.
Publicado 2020

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado 2016