The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

por Brezski, Randall J., Knight, David M., Jordan, Robert E.
Publicado 2011

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

por Jordan, Robert E., Fan, Xuejun, Salazar, Georgina, Zhang, Ningyan, An, Zhiqiang
Publicado 2018

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

por Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Publicado 2018

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

por Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Publicado 2015

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

por Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Publicado 2012

Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

por Fan, Xuejun, Yuan, Zihao, Zhao, Yueshui, Xiong, Wei, Hsiao, Hao-Ching, Pare, Rahmawati, Ding, Jianmin, Almosa, Ahmad, Sun, Kai, Zhang, Songlin, Jordan, Robert E., Lee, Cheok Song, An, Zhiqiang, Zhang, Ningyan
Publicado 2022