P433: PHARMACOLOGICAL DUAL INHIBITION OF PARP AND TIP60 AS A PROSPECTIVE THERAPEUTIC REGIMEN INDUCES SYNERGISTIC AML CELL DEATH

por Ju Park, Tae, Wheadon, Helen, Monaghan, Laura, Huang, Xu, Jorgensen, Heather
Publicado 2023

Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence

por Darici, Salihanur, Alkhaldi, Hazem, Horne, Gillian, Jørgensen, Heather G., Marmiroli, Sandra, Huang, Xu
Publicado 2020

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

por Toofan, Parto, Busch, Caroline, Morrison, Heather, O’Brien, Stephen, Jørgensen, Heather, Copland, Mhairi, Wheadon, Helen
Publicado 2018

The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

por Monaghan, Laura, Massett, Matthew E., Bunschoten, Roderick P., Hoose, Alex, Pirvan, Petrisor-Alin, Liskamp, Robert M. J., Jørgensen, Heather G., Huang, Xu
Publicado 2019

Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy

por Gómez-Castañeda, Eduardo, Hopcroft, Lisa E. M., Rogers, Simon, Munje, Chinmay, Bittencourt-Silvestre, Joana, Copland, Mhairi, Vetrie, David, Holyoake, Tessa, Jørgensen, Heather G.
Publicado 2022

Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia

por Laidlaw, Kamilla M.E., Berhan, Samuel, Liu, Suhu, Silvestri, Giovannino, Holyoake, Tessa L., Frank, David A., Aggarwal, Bharat, Bonner, Michael Y., Perrotti, Danilo, Jørgensen, Heather G., Arbiser, Jack L.
Publicado 2016

A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival

por Massett, Matthew E., Monaghan, Laura, Patterson, Shaun, Mannion, Niamh, Bunschoten, Roderick P., Hoose, Alex, Marmiroli, Sandra, Liskamp, Robert M. J., Jørgensen, Heather G., Vetrie, David, Michie, Alison M., Huang, Xu
Publicado 2021

Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1–BCR-ABL–JAK2 Complex

por Chen, Min, Gallipoli, Paolo, DeGeer, Donna, Sloma, Ivan, Forrest, Donna L., Chan, Matthew, Lai, Damian, Jorgensen, Heather, Ringrose, Ashley, Wang, Hui Mi, Lambie, Karen, Nakamoto, Helen, Saw, Kyi Min, Turhan, Ali, Arlinghaus, Ralph, Paul, James, Stobo, Jon, Barnett, Michael J., Eaves, Allen, Eaves, Connie J, Holyoake, Tessa L., Jiang, Xiaoyan
Publicado 2013