Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

por Kumar, Prashant, Bird, Christopher, Holland, David, Joshi, Sangeeta B., Volkin, David B.
Publicado 2022

Crystallization of a nonreplicating rotavirus vaccine candidate

por Hong, Moo Sun, Kaur, Kawaljit, Sawant, Nishant, Joshi, Sangeeta B., Volkin, David B., Braatz, Richard D.
Publicado 2021

Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array

por Wan, Ying, Hickey, John M., Bird, Christopher, Witham, Katey, Fahey, Paul, Forster, Angus, Joshi, Sangeeta B., Volkin, David B.
Publicado 2018

Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the Nanopatch(TM) Microneedle Delivery System

por Wan, Ying, Gupta, Vineet, Bird, Christopher, Pullagurla, Swathi R., Fahey, Paul, Forster, Angus, Volkin, David B., Joshi, Sangeeta B.
Publicado 2021

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

por Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado 2017

Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine

por Agarwal, Sanjeev, Sahni, Neha, Hickey, John M., Robertson, George A., Sitrin, Robert, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

por Lee, Shwu-Maan, Hickey, John M., Miura, Kazutoyo, Joshi, Sangeeta B., Volkin, David B., King, C. Richter, Plieskatt, Jordan L.
Publicado 2020

Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice...

por Xiao, Yuhong, Zeng, Yuhong, Schante, Carole, Joshi, Sangeeta B., Buchman, George W., Volkin, David B., Middaugh, C. Russell, Isaacs, Stuart N.
Publicado 2020

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

por Kumar, Prashant, Wang, Michael, Kumru, Ozan S., Hickey, John M., Sanmiguel, Julio, Zabaleta, Nerea, Vandenberghe, Luk H., Joshi, Sangeeta B., Volkin, David B.
Publicado 2023

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant

por Toprani, Vishal M., Hickey, John M., Sahni, Neha, Toth, Ronald T., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado 2017

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies

por Patel, Ashaben, Gupta, Vineet, Hickey, John, Nightlinger, Nancy S., Rogers, Richard S., Siska, Christine, Joshi, Sangeeta B., Seaman, Michael S., Volkin, David B., Kerwin, Bruce A.
Publicado 2018

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

por Lee, Shwu-Maan, Wu, Yimin, Hickey, John M., Miura, Kazutoyo, Whitaker, Neal, Joshi, Sangeeta B., Volkin, David B., Richter King, C., Plieskatt, Jordan
Publicado 2019

Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

por Hu, Yue, Kumru, Ozan S., Xiong, Jian, Antunez, Lorena R., Hickey, John, Wang, Yang, Cavacini, Lisa, Klempner, Mark, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020

Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens

por Agarwal, Sanjeev, Hickey, John M., McAdams, David, White, Jessica A., Sitrin, Robert, Khandke, Lakshmi, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020

Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens

por Agarwal, Sanjeev, Hickey, John M., Sahni, Neha, IV, Ronald T. Toth, Robertson, George A., Sitrin, Robert, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publicado 2019

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation...

por Velez‐Suberbie, M. Lourdes, Morris, Stephen A., Kaur, Kawaljit, Hickey, John M., Joshi, Sangeeta B., Volkin, David B., Bracewell, Daniel G., Mukhopadhyay, Tarit K.
Publicado 2020

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines

por Kumru, Ozan S., Sanyal, Mrinmoy, Friedland, Natalia, Hickey, John, Joshi, Richa, Weidenbacher, Payton, Do, Jonathan, Cheng, Ya-Chen, Kim, Peter S., Joshi, Sangeeta B., Volkin, David B.
Publicado 2023

Measurement of Adenovirus-Based Vector Heterogeneity

por Hickey, John M., Jacob, Shaleem I., Tait, Andrew S., Vahid, Fatemeh Dastjerdi, Barritt, Joseph, Rouse, Sarah, Douglas, Alexander, Joshi, Sangeeta B., Volkin, David B., Bracewell, Daniel G.
Publicado 2023

Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery

por Kumar, Prashant, Pullagurla, Swathi R., Patel, Ashaben, Shukla, Ravi S., Bird, Christopher, Kumru, Ozan S., Hamidi, Ahd, Hoeksema, Femke, Yallop, Christopher, Bines, Julie E., Joshi, Sangeeta B., Volkin, David B.
Publicado 2021

Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine

por Kumru, Ozan S., Saleh-Birdjandi, Soraia, Antunez, Lorena R., Sayeed, Eddy, Robinson, David, van den Worm, Sjoerd, Diemer, Geoffrey S., Perez, Wilma, Caposio, Patrizia, Früh, Klaus, Joshi, Sangeeta B., Volkin, David B.
Publicado 2019