Developmental roles and molecular mechanisms of Asterix/GTSF1

por Ipsaro, Jonathan J., Joshua‐Tor, Leemor
Publicado 2022

Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway

por Faehnle, Christopher R., Walleshauser, Jack, Joshua-Tor, Leemor
Publicado 2014

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

por Faehnle, Christopher R., Walleshauser, Jack, Joshua-Tor, Leemor
Publicado 2017

A shape-shifting nuclease unravels structured RNA

por Meze, Katarina, Axhemi, Armend, Thomas, Dennis R., Doymaz, Ahmet, Joshua-Tor, Leemor
Publicado 2023

The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS

por Schalch, Thomas, Job, Godwin, Shanker, Sreenath, Partridge, Janet F., Joshua-Tor, Leemor
Publicado 2011

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

por Bibel, Brianna, Elkayam, Elad, Silletti, Steve, Komives, Elizabeth A, Joshua-Tor, Leemor
Publicado 2022

The dynamic nature of the human origin recognition complex revealed through five cryoEM structures

por Jaremko, Matt J, On, Kin Fan, Thomas, Dennis R, Stillman, Bruce, Joshua-Tor, Leemor
Publicado 2020

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

por Ipsaro, Jonathan J., Haase, Astrid D., Knott, Simon R., Joshua-Tor, Leemor, Hannon, Gregory J.
Publicado 2012

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

por Jung, James, Grant, Timothy, Thomas, Dennis R., Diehnelt, Chris W., Grigorieff, Nikolaus, Joshua-Tor, Leemor
Publicado 2019

Structure of the active form of human origin recognition complex and its ATPase motor module

por Tocilj, Ante, On, Kin Fan, Yuan, Zuanning, Sun, Jingchuan, Elkayam, Elad, Li, Huilin, Stillman, Bruce, Joshua-Tor, Leemor
Publicado 2017

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

por Elkayam, Elad, Parmar, Rubina, Brown, Christopher R., Willoughby, Jennifer L., Theile, Christopher S., Manoharan, Muthiah, Joshua-Tor, Leemor
Publicado 2017

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

por Elkayam, Elad, Parmar, Rubina, Brown, Christopher R., Willoughby, Jennifer L., Theile, Christopher S., Manoharan, Muthiah, Joshua-Tor, Leemor
Publicado 2017

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis

por Ipsaro, Jonathan J., Shen, Chen, Arai, Eri, Xu, Yali, Kinney, Justin B., Joshua-Tor, Leemor, Vakoc, Christopher R., Shi, Junwei
Publicado 2017

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

por Krishnan, Navasona, Bonham, Christopher A., Rus, Ioana A., Shrestha, Om Kumar, Gauss, Carla M., Haque, Aftabul, Tocilj, Ante, Joshua-Tor, Leemor, Tonks, Nicholas K.
Publicado 2018

Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

por Stein, Chad B., Genzor, Pavol, Mitra, Sanga, Elchert, Alexandra R., Ipsaro, Jonathan J., Benner, Leif, Sobti, Sushil, Su, Yijun, Hammell, Molly, Joshua-Tor, Leemor, Haase, Astrid D.
Publicado 2019

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

por Wang, Pengfei, Liu, Lihong, Nair, Manoj S., Yin, Michael T., Luo, Yang, Wang, Qian, Yuan, Ting, Mori, Kanako, Solis, Axel Guzman, Yamashita, Masahiro, Garg, Ankur, Purpura, Lawrence J., Laracy, Justin C., Yu, Jian, Joshua-Tor, Leemor, Sodroski, Joseph, Huang, Yaoxing, Ho, David D.
Publicado 2020

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

por Lee, Seung Cho, Adams, Dexter W., Ipsaro, Jonathan J., Cahn, Jonathan, Lynn, Jason, Kim, Hyun-Soo, Berube, Benjamin, Major, Viktoria, Calarco, Joseph P., LeBlanc, Chantal, Bhattacharjee, Sonali, Ramu, Umamaheswari, Grimanelli, Daniel, Jacob, Yannick, Voigt, Philipp, Joshua-Tor, Leemor, Martienssen, Robert A.
Publicado 2023

Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation

por Lee, Seung Cho, Adams, Dexter W., Ipsaro, Jonathan J., Cahn, Jonathan, Lynn, Jason, Kim, Hyun-Soo, Berube, Benjamin, Major, Viktoria, Calarco, Joseph P., LeBlanc, Chantal, Bhattacharjee, Sonali, Ramu, Umamaheswari, Grimanelli, Daniel, Jacob, Yannick, Voigt, Philipp, Joshua-Tor, Leemor, Martienssen, Robert A.
Publicado 2023