Environmental variables and genome-environment interactions predicting IBD diagnosis in large UK cohort

por Yang, Alan Z., Jostins-Dean, Luke
Publicado 2022

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

por Ryzhakov, Grigory, Almuttaqi, Hannah, Corbin, Alastair L., Berthold, Dorothée L., Khoyratty, Tariq, Eames, Hayley L., Bullers, Samuel, Pearson, Claire, Ai, Zhichao, Zec, Kristina, Bonham, Sarah, Fischer, Roman, Jostins-Dean, Luke, Travis, Simon P. L., Kessler, Benedikt M., Udalova, Irina A.
Publicado 2021

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background

por Zhang, Cong, Shestopaloff, Konstantin, Hollis, Benjamin, Kwok, Chun Hei, Hon, Claudia, Hartmann, Nicole, Tian, Chengeng, Wozniak, Magdalena, Santos, Luis, West, Dominique, Gardiner, Stephen, Mallon, Ann-Marie, Readie, Aimee, Martin, Ruvie, Nichols, Thomas, Beste, Michael T., Zierer, Jonas, Ferrero, Enrico, Vandemeulebroecke, Marc, Jostins-Dean, Luke
Publicado 2023

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

por Mukhopadhyay, Subhankar, Heinz, Eva, Porreca, Immacolata, Alasoo, Kaur, Yeung, Amy, Yang, Huei-Ting, Schwerd, Tobias, Forbester, Jessica L., Hale, Christine, Agu, Chukwuma A., Choi, Yoon Ha, Rodrigues, Julia, Capitani, Melania, Jostins-Dean, Luke, Thomas, David C., Travis, Simon, Gaffney, Daniel, Skarnes, William C., Thomson, Nicholas, Uhlig, Holm H., Dougan, Gordon, Powrie, Fiona
Publicado 2019