Lenalidomide Stabilizes Protein–Protein Complexes by Turning Labile Intermolecular H-Bonds into Robust Interactions

por Miñarro-Lleonar, Marina, Bertran-Mostazo, Andrea, Duro, Jorge, Barril, Xavier, Juárez-Jiménez, Jordi
Publicado 2023

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

por Di Pietro, Ornella, Juárez-Jiménez, Jordi, Muñoz-Torrero, Diego, Laughton, Charles A., Luque, F. Javier
Publicado 2017

Correction: Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

por Di Pietro, Ornella, Juárez-Jiménez, Jordi, Muñoz-Torrero, Diego, Laughton, Charles A., Luque, F. Javier
Publicado 2017

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

por Juárez-Jiménez, Jordi, Gupta, Arun A., Karunanithy, Gogulan, Mey, Antonia S. J. S., Georgiou, Charis, Ioannidis, Harris, De Simone, Alessio, Barlow, Paul N., Hulme, Alison N., Walkinshaw, Malcolm D., Baldwin, Andrew J., Michel, Julien
Publicado 2020

Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus

por Rey-Carrizo, Matias, Barniol-Xicota, Marta, Ma, Chunlong, Frigolé-Vivas, Marta, Torres, Eva, Naesens, Lieve, Llabrés, Salomé, Juárez-Jiménez, Jordi, Luque, Francisco J., DeGrado, William F., Lamb, Robert A., Pinto, Lawrence H., Vázquez, Santiago
Publicado 2014

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

por De Simone, Alessio, Georgiou, Charis, Ioannidis, Harris, Gupta, Arun A., Juárez-Jiménez, Jordi, Doughty-Shenton, Dahlia, Blackburn, Elizabeth A., Wear, Martin A., Richards, Jonathan P., Barlow, Paul N., Carragher, Neil, Walkinshaw, Malcolm D., Hulme, Alison N., Michel, Julien
Publicado 2018

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

por Codony, Sandra, Pont, Caterina, Griñán-Ferré, Christian, Di Pede-Mattatelli, Ania, Calvó-Tusell, Carla, Feixas, Ferran, Osuna, Sílvia, Jarné-Ferrer, Júlia, Naldi, Marina, Bartolini, Manuela, Loza, María Isabel, Brea, José, Pérez, Belén, Bartra, Clara, Sanfeliu, Coral, Juárez-Jiménez, Jordi, Morisseau, Christophe, Hammock, Bruce D., Pallàs, Mercè, Vázquez, Santiago, Muñoz-Torrero, Diego
Publicado 2022

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

por Scott, Jamie I., Mendive-Tapia, Lorena, Gordon, Doireann, Barth, Nicole D., Thompson, Emily J., Cheng, Zhiming, Taggart, David, Kitamura, Takanori, Bravo-Blas, Alberto, Roberts, Edward W., Juarez-Jimenez, Jordi, Michel, Julien, Piet, Berber, de Vries, I. Jolanda, Verdoes, Martijn, Dawson, John, Carragher, Neil O., Connor, Richard A. O’, Akram, Ahsan R., Frame, Margaret, Serrels, Alan, Vendrell, Marc
Publicado 2022