Castration-Resistant Lgr5(+) Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration

por Wang, Bu-er, Wang, Xi, Long, Jason E., Eastham-Anderson, Jeff, Firestein, Ron, Junttila, Melissa R.
Publicado 2015

Selective activation of p53-mediated tumour suppression in high-grade tumours

por Junttila, Melissa R., Karnezis, Anthony, Garcia, Daniel, Madriles, Francesc, Kortlever, Roderik M., Rostker, Fanya, Brown-Swigart, Lamorna, Pham, David M., Seo, Youngho, Evan, Gerard I., Martins, Carla P.
Publicado 2010

Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis()

por Barck, Kai H., Bou-Reslan, Hani, Rastogi, Ujjawal, Sakhuja, Timothy, Long, Jason E., Molina, Rafael, Lima, Anthony, Hamilton, Patricia, Junttila, Melissa R., Johnson, Leisa, Carano, Richard A.D.
Publicado 2015

Automated segmentation of lungs and lung tumors in mouse micro-CT scans

por Ferl, Gregory Z., Barck, Kai H., Patil, Jasmine, Jemaa, Skander, Malamut, Evelyn J., Lima, Anthony, Long, Jason E., Cheng, Jason H., Junttila, Melissa R., Carano, Richard A.D.
Publicado 2022

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

por Chung, Wei-Jen, Daemen, Anneleen, Cheng, Jason H., Long, Jason E., Cooper, Jonathan E., Wang, Bu-er, Tran, Christopher, Singh, Mallika, Gnad, Florian, Modrusan, Zora, Foreman, Oded, Junttila, Melissa R.
Publicado 2017

EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS (G12D) tumor development and propagation

por Pribluda, Ariel, Daemen, Anneleen, Lima, Anthony Nelson, Wang, Xi, Hafner, Marc, Poon, Chungkee, Modrusan, Zora, Katakam, Anand Kumar, Foreman, Oded, Eastham, Jefferey, Hung, Jefferey, Haley, Benjamin, Garcia, Julia T, Jackson, Erica L, Junttila, Melissa R
Publicado 2022

A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

por Dorso, M., Patel, Payal T., Pankov, Aleksandr, Boyer, Jacob A., Soni, Rajesh K., Del Priore, Isabella S., Hayatt, Omar, Kulick, Amanda, Hagen, Connor J., de Stanchina, Elisa, Junttila, Melissa R., Daemen, Anneleen, Friedman, Lori S., Hendrickson, Ronald C., Chandarlapaty, Sarat
Publicado 2023

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

por López-Arribillaga, Erika, Rodilla, Verónica, Colomer, Carlota, Vert, Anna, Shelton, Amy, Cheng, Jason H., Yan, Bing, Gonzalez-Perez, Abel, Junttila, Melissa R., Iglesias, Mar, Torres, Ferran, Albanell, Joan, Villanueva, Alberto, Bigas, Anna, Siebel, Christian W., Espinosa, LLuís
Publicado 2018

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

por Long, Jason E., Wongchenko, Matthew J., Nickles, Dorothee, Chung, Wei-Jen, Wang, Bu-er, Riegler, Johannes, Li, Ji, Li, Qingling, Sandoval, Wendy, Eastham-Anderson, Jeff, Modrusan, Zora, Junttila, Teemu, Carano, Richard A. D., Foreman, Oded, Yan, Yibing, Junttila, Melissa R.
Publicado 2019

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

por Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Publicado 2017

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

por Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Publicado 2018

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

por Catenacci, Daniel V.T., Junttila, Melissa R., Karrison, Theodore, Bahary, Nathan, Horiba, Margit N., Nattam, Sreenivasa R., Marsh, Robert, Wallace, James, Kozloff, Mark, Rajdev, Lakshmi, Cohen, Deirdre, Wade, James, Sleckman, Bethany, Lenz, Heinz-Josef, Stiff, Patrick, Kumar, Pankaj, Xu, Peng, Henderson, Les, Takebe, Naoko, Salgia, Ravi, Wang, Xi, Stadler, Walter M., de Sauvage, Frederic J., Kindler, Hedy L.
Publicado 2015

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

por Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj
Publicado 2019

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

por Munne, Pauliina M., Martikainen, Lahja, Räty, Iiris, Bertula, Kia, Nonappa, Ruuska, Janika, Ala-Hongisto, Hanna, Peura, Aino, Hollmann, Babette, Euro, Lilya, Yavuz, Kerim, Patrikainen, Linda, Salmela, Maria, Pokki, Juho, Kivento, Mikko, Väänänen, Juho, Suomi, Tomi, Nevalaita, Liina, Mutka, Minna, Kovanen, Panu, Leidenius, Marjut, Meretoja, Tuomo, Hukkinen, Katja, Monni, Outi, Pouwels, Jeroen, Sahu, Biswajyoti, Mattson, Johanna, Joensuu, Heikki, Heikkilä, Päivi, Elo, Laura L., Metcalfe, Ciara, Junttila, Melissa R., Ikkala, Olli, Klefström, Juha
Publicado 2021