Senescence explains age- and obesity-related liver steatosis

por Ogrodnik, Mikolaj, Jurk, Diana
Publicado 2017

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

por Lawless, Conor, Jurk, Diana, Gillespie, Colin S., Shanley, Daryl, Saretzki, Gabriele, von Zglinicki, Thomas, Passos, João F.
Publicado 2012

A senescent cell bystander effect: senescence-induced senescence

por Nelson, Glyn, Wordsworth, James, Wang, Chunfang, Jurk, Diana, Lawless, Conor, Martin-Ruiz, Carmen, von Zglinicki, Thomas
Publicado 2012

Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis

por Jalan-Sakrikar, Nidhi, Anwar, Abid, Yaqoob, Usman, Gan, Can, Lagnado, Anthony B., Wixom, Alexander Q., Jurk, Diana, Huebert, Robert C.
Publicado 2023

Adult-onset, short-term dietary restriction reduces cell senescence in mice

por Wang, Chunfang, Maddick, Mandy, Miwa, Satomi, Jurk, Diana, Czapiewski, Rafal, Saretzki, Gabriele, Langie, Sabine A.S., Godschalk, Roger W.L., Cameron, Kerry, von Zglinicki, Thomas
Publicado 2010

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

por Hewitt, Graeme, Jurk, Diana, Marques, Francisco D.M., Correia-Melo, Clara, Hardy, Timothy, Gackowska, Agata, Anderson, Rhys, Taschuk, Morgan, Mann, Jelena, Passos, João F.
Publicado 2012

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

por Jurk, Diana, Wang, Chunfang, Miwa, Satomi, Maddick, Mandy, Korolchuk, Viktor, Tsolou, Avgi, Gonos, Efstathios S, Thrasivoulou, Christopher, Jill Saffrey, M, Cameron, Kerry, von Zglinicki, Thomas
Publicado 2012

Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition

por Ekpenyong‐Akiba, Akang E., Poblocka, Marta, Althubiti, Mohammad, Rada, Miran, Jurk, Diana, Germano, Sandra, Kocsis‐Fodor, Gabriella, Shi, Yu, Canales, Juan J., Macip, Salvador
Publicado 2019

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1 (−/−) mice

por Fielder, Edward, Tweedy, Clare, Wilson, Caroline, Oakley, Fiona, LeBeau, Fiona E. N., Passos, João F., Mann, Derek A., von Zglinicki, Thomas, Jurk, Diana
Publicado 2020

A chronic wound model to investigate skin cellular senescence

por Wyles, Saranya P., Dashti, Parisa, Pirtskhalava, Tamar, Tekin, Burak, Inman, Christina, Gomez, Lilian Sales, Lagnado, Anthony B., Prata, Larissa, Jurk, Diana, Passos, João F., Tchkonia, Tamar, Kirkland, James L.
Publicado 2023

Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis

por Bianchi, Arianna, Marchetti, Letizia, Hall, Zoe, Lemos, Henrique, Vacca, Michele, Paish, Hannah, Green, Kile, Elliott, Bronte, Tiniakos, Dina, Passos, João F., Jurk, Diana, Mann, Derek A., Wilson, Caroline L.
Publicado 2021

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

por Fielder, Edward, Wan, Tengfei, Alimohammadiha, Ghazaleh, Ishaq, Abbas, Low, Evon, Weigand, B Melanie, Kelly, George, Parker, Craig, Griffin, Brigid, Jurk, Diana, Korolchuk, Viktor I, von Zglinicki, Thomas, Miwa, Satomi
Publicado 2022

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

por Xu, Ming, Bradley, Elizabeth W., Weivoda, Megan M., Hwang, Soyun M., Pirtskhalava, Tamar, Decklever, Teresa, Curran, Geoffry L., Ogrodnik, Mikolaj, Jurk, Diana, Johnson, Kurt O., Lowe, Val, Tchkonia, Tamar, Westendorf, Jennifer J., Kirkland, James L.
Publicado 2017

Rapamycin improves healthspan but not inflammaging in nfκb1 (−/−) mice

por Correia‐Melo, Clara, Birch, Jodie, Fielder, Edward, Rahmatika, Dina, Taylor, Jennifer, Chapman, James, Lagnado, Anthony, Carroll, Bernadette M., Miwa, Satomi, Richardson, Gavin, Jurk, Diana, Oakley, Fiona, Mann, Jelena, Mann, Derek A., Korolchuk, Viktor I., Passos, João F.
Publicado 2018

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

por Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.
Publicado 2016

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

por Birch, Jodie, Anderson, Rhys K., Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J., Moisey, Elizabeth, Birrell, Mark A., Belvisi, Maria G., Black, Fiona, Taylor, John J., Fisher, Andrew J., De Soyza, Anthony, Passos, João F.
Publicado 2015

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

por Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Publicado 2016

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

por Cassidy, Liam D., Young, Andrew R. J., Young, Christopher N. J., Soilleux, Elizabeth J., Fielder, Edward, Weigand, Bettina M., Lagnado, Anthony, Brais, Rebecca, Ktistakis, Nicholas T., Wiggins, Kimberley A., Pyrillou, Katerina, Clarke, Murray C. H., Jurk, Diana, Passos, Joao F., Narita, Masashi
Publicado 2020

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

por Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Publicado 2014

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

por Carroll, Bernadette, Otten, Elsje G., Manni, Diego, Stefanatos, Rhoda, Menzies, Fiona M., Smith, Graham R., Jurk, Diana, Kenneth, Niall, Wilkinson, Simon, Passos, Joao F., Attems, Johannes, Veal, Elizabeth A., Teyssou, Elisa, Seilhean, Danielle, Millecamps, Stéphanie, Eskelinen, Eeva-Liisa, Bronowska, Agnieszka K., Rubinsztein, David C., Sanz, Alberto, Korolchuk, Viktor I.
Publicado 2018