Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

por Juvvadi, Praveen R, Steinbach, William J
Publicado 2015

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis

por Lamoth, Frédéric, Juvvadi, Praveen R., Steinbach, William J.
Publicado 2015

Editorial: Advances in Aspergillus fumigatus Pathobiology

por Lamoth, Frédéric, Juvvadi, Praveen R., Steinbach, William J.
Publicado 2016

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus

por Juvvadi, Praveen R., Bobay, Benjamin G., Cole, D. Christopher, Awwa, Monaf, Steinbach, William J.
Publicado 2022

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus

por Falloon, Katie, Juvvadi, Praveen R., Richards, Amber D., Vargas-Muñiz, José M., Renshaw, Hilary, Steinbach, William J.
Publicado 2015

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Asperg...

por Juvvadi, Praveen R., Ma, Yan, Richards, Amber D., Soderblom, Erik J., Moseley, M. Arthur, Lamoth, Frédéric, Steinbach, William J.
Publicado 2015

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus

por Juvvadi, Praveen R., Muñoz, Alberto, Lamoth, Frédéric, Soderblom, Erik J., Moseley, M. Arthur, Read, Nick D., Steinbach, William J.
Publicado 2015

A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus

por Shwab, E. Keats, Juvvadi, Praveen R., Waitt, Greg, Soderblom, Erik J., Moseley, M. Arthur, Nicely, Nathan I., Asfaw, Yohannes G., Steinbach, William J.
Publicado 2017

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

por Gobeil, Sophie M.-C., Bobay, Benjamin G., Juvvadi, Praveen R., Cole, D. Christopher, Heitman, Joseph, Steinbach, William J., Venters, Ronald A., Spicer, Leonard D.
Publicado 2021

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus

por Vargas-Muñiz, José M., Renshaw, Hilary, Richards, Amber D., Waitt, Greg, Soderblom, Erik J., Moseley, Martin. A., Asfaw, Yohannes, Juvvadi, Praveen R., Steinbach, William J.
Publicado 2016

Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus

por Shwab, E. Keats, Juvvadi, Praveen R., Shaheen, Shareef K., Allen, John, Waitt, Greg, Soderblom, Erik J., Asfaw, Yohannes G., Moseley, M. Arthur, Steinbach, William J.
Publicado 2022

The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets

por Shwab, E. Keats, Juvvadi, Praveen R., Waitt, Greg, Shaheen, Shareef, Allen, John, Soderblom, Erik J., Bobay, Benjamin G., Asfaw, Yohannes G., Moseley, M. Arthur, Steinbach, William J.
Publicado 2020

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

por Juvvadi, Praveen R., Gehrke, Christopher, Fortwendel, Jarrod R., Lamoth, Frédéric, Soderblom, Erik J., Cook, Erik C., Hast, Michael A., Asfaw, Yohannes G., Moseley, M. Arthur, Creamer, Trevor P., Steinbach, William J.
Publicado 2013

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans

por Rivera, Angela, Young Lim, Won, Park, Eunchong, Dome, Patrick A., Hoy, Michael J., Spasojevic, Ivan, Sun, Sheng, Averette, Anna Floyd, Pina-Oviedo, Sergio, Juvvadi, Praveen R., Steinbach, William J., Ciofani, Maria, Hong, Jiyong, Heitman, Joseph
Publicado 2023

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

por Hoy, Michael J., Park, Eunchong, Lee, Hyunji, Lim, Won Young, Cole, D. Christopher, DeBouver, Nicholas D., Bobay, Benjamin G., Pierce, Phillip G., Fox, David, Ciofani, Maria, Juvvadi, Praveen R., Steinbach, William, Hong, Jiyong, Heitman, Joseph
Publicado 2022

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

por Juvvadi, Praveen R., Fox, David, Bobay, Benjamin G., Hoy, Michael J., Gobeil, Sophie M. C., Venters, Ronald A., Chang, Zanetta, Lin, Jackie J., Averette, Anna Floyd, Cole, D. Christopher, Barrington, Blake C., Wheaton, Joshua D., Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D., Schumacher, Maria A., Heitman, Joseph, Steinbach, William J.
Publicado 2019