Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

por Köcher, Sabrina, Rieckmann, Thorsten, Rohaly, Gabor, Mansour, Wael Y., Dikomey, Ekkehard, Dornreiter, Irena, Dahm-Daphi, Jochen
Publicado 2012

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

por Bakr, Ali, Köcher, Sabrina, Volquardsen, Jennifer, Petersen, Cordula, Borgmann, Kerstin, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y.
Publicado 2016

Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell lines

por Riedel, Matthias, Struve, Nina, Müller-Goebel, Justus, Köcher, Sabrina, Petersen, Cordula, Dikomey, Ekkehard, Rothkamm, Kai, Kriegs, Malte
Publicado 2016

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-...

por Schötz, Ulrike, Balzer, Viola, Brandt, Friedrich-Wilhelm, Ziemann, Frank, Subtil, Florentine S.B., Rieckmann, Thorsten, Köcher, Sabrina, Engenhart-Cabillic, Rita, Dikomey, Ekkehard, Wittig, Andrea, Arenz, Andrea
Publicado 2020

A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells

por Köcher, Sabrina, Zech, Henrike Barbara, Krug, Leonie, Gatzemeier, Fruzsina, Christiansen, Sabrina, Meyer, Felix, Rietow, Ruth, Struve, Nina, Mansour, Wael Yassin, Kriegs, Malte, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Rieckmann, Thorsten
Publicado 2022

Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

por Oetting, Agnes, Christiansen, Sabrina, Gatzemeier, Fruzsina, Köcher, Sabrina, Bußmann, Lara, Böttcher, Arne, Stölzel, Katharina, Hoffmann, Anna Sophie, Struve, Nina, Kriegs, Malte, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Zech, Henrike Barbara, Rieckmann, Thorsten
Publicado 2023

Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair

por Elsesy, Mohamed E., Oh-Hohenhorst, Su Jung, Löser, Anastassia, Oing, Christoph, Mutiara, Sally, Köcher, Sabrina, Meien, Stefanie, Zielinski, Alexandra, Burdak-Rothkamm, Susanne, Tilki, Derya, Huland, Hartwig, Schwarz, Rudolf, Petersen, Cordula, Bokemeyer, Carsten, Rothkamm, Kai, Mansour, Wael Y.
Publicado 2020

MEDB-50. Assessment of cellular radiosensitivity and DNA repair in medulloblastoma cell lines and patient-derivded xenograft slice cultures

por Feyerabend, Simon, Rieckmann, Thorsten, Riepen, Britta, Oetting, Agnes, Christiansen, Sabrina, Schoof, Melanie, Hardt, Annika, Köcher, Sabrina, Neumann, Julia, Schwarz, Rudolf, Mack, Norman, Schwalm, Benjamin, Federico, Aniello, Milde, Till, Kool, Marcel, Schüller, Ulrich, Rutkowski, Stefan, Petersen, Cordula, Rothkamm, Kai, Mynarek, Martin, Struve, Nina
Publicado 2022