Relevance and consequence of chronic inflammation for obesity development

por Ruck, Lisa, Wiegand, Susanna, Kühnen, Peter
Publicado 2023

Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity

por Overberg, Johanna, Kalveram, Laura, Keller, Theresa, Krude, Heiko, Kühnen, Peter, Wiegand, Susanna
Publicado 2022

Timing of Onset of Adverse Events With Setmelanotide, an MC4R Agonist, in Patients With Severe Obesity Due to LEPR or POMC Deficiency

por Clément, Karine, van den Akker, Erica L T, Gordon, Gregory, Yuan, Guojun, Kühnen, Peter
Publicado 2021

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

por Reininghaus, Nanina, Paisdzior, Sarah, Höpfner, Friederike, Jyrch, Sabine, Cetindag, Cigdem, Scheerer, Patrick, Kühnen, Peter, Biebermann, Heike
Publicado 2022

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

por Höpfner, Friederike, Paisdzior, Sarah, Reininghaus, Nanina, Sohail, Iqra, Scheerer, Patrick, Annibale, Paolo, Biebermann, Heike, Kühnen, Peter
Publicado 2022

Understanding the Patient Experience of Hunger and Improved Quality of Life with Setmelanotide Treatment in POMC and LEPR Deficiencies

por Wabitsch, Martin, Fehnel, Sheri, Mallya, Usha G., Sluga-O’Callaghan, Martina, Richardson, David, Price, Mark, Kühnen, Peter
Publicado 2022

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength

por Schwiebert, Christian, Kühnen, Peter, Becker, Niels-Peter, Welsink, Tim, Keller, Theresa, Minich, Waldemar B., Wiegand, Susanna, Schomburg, Lutz
Publicado 2020

ODP607 Long-term Efficacy of Setmelanotide in Patients With POMC or LEPR Deficiency Obesity

por Clément, Karine, Wabitsch, Martin, Van den Akker, Erica, Argente, Jesús, Scimia, Ceclila, Srinivasan, Madhura, Yuan, Guojun, Kühnen, Peter
Publicado 2022

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

por Paisdzior, Sarah, Dimitriou, Ioanna Maria, Schöpe, Paul Curtis, Annibale, Paolo, Scheerer, Patrick, Krude, Heiko, Lohse, Martin J., Biebermann, Heike, Kühnen, Peter
Publicado 2020

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10

por Porst, Theresa, Johannes, Jörg, Gluschke, Hans, Köhler, Richard, Mehl, Sebastian, Kühnen, Peter, Renko, Kostja, Minich, Waldemar B., Wiegand, Susanna, Schomburg, Lutz
Publicado 2021

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide

por Wabitsch, Martin, Farooqi, Sadaf, Flück, Christa E, Bratina, Natasa, Mallya, Usha G, Stewart, Murray, Garrison, Jill, van den Akker, Erica, Kühnen, Peter
Publicado 2022

OR07-01 Aberrant Expression Of Agouti Signaling Protein (ASIP) As A Cause of Monogenic Severe Childhood Obesity

por Landgraf, Kathrin, Kempf, Elena Tamara, Stein, Robert, Hanschkow, Martha, Kühnen, Peter, Tseng, Yu-Hua, Schöneberg, Torsten, Zeggini, Eleftheria, Kiess, Wieland, Blüher, Matthias, Körner, Antje
Publicado 2023

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

por Heyder, Nicolas, Kleinau, Gunnar, Szczepek, Michal, Kwiatkowski, Dennis, Speck, David, Soletto, Lucia, Cerdá-Reverter, José Miguel, Krude, Heiko, Kühnen, Peter, Biebermann, Heike, Scheerer, Patrick
Publicado 2019

Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency

por Kühnen, Peter, Wabitsch, Martin, von Schnurbein, Julia, Chirila, Costel, Mallya, Usha G., Callahan, Patrick, Gnanasakthy, Ari, Poitou, Christine, Krabusch, Philipp M., Stewart, Murray, Clément, Karine
Publicado 2022

Tissue Sodium Content and Arterial Hypertension in Obese Adolescents

por Roth, Sophie, Markó, Lajos, Birukov, Anna, Hennemuth, Anja, Kühnen, Peter, Jones, Alexander, Ghorbani, Niky, Linz, Peter, Müller, Dominik N, Wiegand, Susanna, Berger, Felix, Kuehne, Titus, Kelm, Marcus
Publicado 2019

GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling

por Narumi, Satoshi, Opitz, Robert, Nagasaki, Keisuke, Muroya, Koji, Asakura, Yumi, Adachi, Masanori, Abe, Kiyomi, Sugisawa, Chiho, Kühnen, Peter, Ishii, Tomohiro, Nöthen, Markus M, Krude, Heiko, Hasegawa, Tomonobu
Publicado 2022

Sleep Timing in Patients with Precocious and Delayed Pubertal Development

por Jessen, Elena, Vetter, Celine, Roenneberg, Till, Liesenkötter, Klaus-Peter, Werner, Helene, Jenni, Oskar G., Lankes, Erwin, Blankenstein, Oliver, Neumann, Uta, Köhler, Birgit, Wiegand, Susanna, Krude, Heiko, Kühnen, Peter
Publicado 2019

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

por Gögebakan, Özlem, Andres, Janin, Biedasek, Katrin, Mai, Knut, Kühnen, Peter, Krude, Heiko, Isken, Frank, Rudovich, Natalia, Osterhoff, Martin A., Kintscher, Ulrich, Nauck, Michael, Pfeiffer, Andreas F.H., Spranger, Joachim
Publicado 2012

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1

por Mühlhaus, Jessica, Dinter, Juliane, Jyrch, Sabine, Teumer, Alexander, Jacobi, Simon F., Homuth, Georg, Kühnen, Peter, Wiegand, Susanna, Grüters, Annette, Völzke, Henry, Raile, Klemens, Kleinau, Gunnar, Krude, Heiko, Biebermann, Heike
Publicado 2017

(68)Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism

por Boss, Marti, Rottenburger, Christof, Brenner, Winfried, Blankenstein, Oliver, Prasad, Vikas, Prasad, Sonal, de Coppi, Paolo, Kühnen, Peter, Buitinga, Mijke, Nuutila, Pirjo, Otonkoski, Timo, Hussain, Khalid, Brom, Maarten, Eek, Annemarie, Bomanji, Jamshed, Shah, Pratik, Gotthardt, Martin
Publicado 2022