Joining Forces for Cancer Treatment: From “TCR versus CAR” to “TCR and CAR”

por Teppert, Karin, Wang, Xueting, Anders, Kathleen, Evaristo, César, Lock, Dominik, Künkele, Annette
Publicado 2022

Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges

por Zappa, Elisa, Vitali, Alice, Anders, Kathleen, Molenaar, Jan J., Wienke, Judith, Künkele, Annette
Publicado 2023

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

por Künkele, Annette, Grosse-Lordemann, Anja, Schramm, Alexander, Eggert, Angelika, Schulte, Johannes H, Bachmann, Hagen S
Publicado 2013

Accelerating clinical-scale production of BCMA CAR T cells with defined maturation stages

por Joedicke, Jara J., Großkinsky, Ulrich, Gerlach, Kerstin, Künkele, Annette, Höpken, Uta E., Rehm, Armin
Publicado 2021

Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma

por Zirngibl, Felix, Flemmig, Carina, Lang, Peter, Künkele, Annette, Eggert, Angelika, Schulte, Johannes H., Deubzer, Hedwig E.
Publicado 2020

Chimeric Antigen Receptor T-Cell Therapy in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia: Curative Treatment Option or Bridge to Transplant?

por Buechner, Jochen, Caruana, Ignazio, Künkele, Annette, Rives, Susana, Vettenranta, Kim, Bader, Peter, Peters, Christina, Baruchel, André, Calkoen, Friso G.
Publicado 2022

Widely applicable, extended flow cytometric stem cell enumeration panel for quality control of advanced cellular products

por Haussmann, Katy, Streitz, Mathias, Takvorian, Anna, Grund, Jana, Skenderi, Zemra, Tietze-Bürger, Carola, Movassaghi, Kamran, Künkele, Annette, Blum, Agnieszka, Bullinger, Lars
Publicado 2022

Case report: HLA-haploidentical HSCT rescued with donor lymphocytes infusions in a patient with X-linked chronic granulomatous disease

por Scheiermann, Julia, Künkele, Annette, von Stackelberg, Arend, Eggert, Angelika, Lang, Peter, Zirngibl, Felix, Martin, Luise, Schulte, Johannes Hubertus, von Bernuth, Horst
Publicado 2023

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma

por Arnhold, Viktor, Schmelz, Karin, Proba, Jutta, Winkler, Annika, Wünschel, Jasmin, Toedling, Joern, Deubzer, Hedwig E., Künkele, Annette, Eggert, Angelika, Schulte, Johannes H., Hundsdoerfer, Patrick
Publicado 2017

Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model

por Mueller-Schoell, Anna, Puebla-Osorio, Nahum, Michelet, Robin, Green, Michael R., Künkele, Annette, Huisinga, Wilhelm, Strati, Paolo, Chasen, Beth, Neelapu, Sattva S., Yee, Cassian, Kloft, Charlotte
Publicado 2021

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status

por Gottlieb, Aline, Althoff, Kristina, Grunewald, Laura, Thor, Theresa, Odersky, Andrea, Schulte, Marc, Deubzer, Hedwig E., Heukamp, Lukas, Eggert, Angelika, Schramm, Alexander, Schulte, Johannes H., Künkele, Annette
Publicado 2017

Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis

por Sulejmani, Ornela, Grunewald, Laura, Andersch, Lena, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Astrahantseff, Kathy, Eggert, Angelika, Henssen, Anton G., Schulte, Johannes H., Anders, Kathleen, Künkele, Annette
Publicado 2021

The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma

por Pajtler, Kristian W, Weingarten, Christina, Thor, Theresa, Künkele, Annette, Heukamp, Lukas C, Büttner, Reinhard, Suzuki, Takayoshi, Miyata, Naoki, Grotzer, Michael, Rieb, Anja, Sprüssel, Annika, Eggert, Angelika, Schramm, Alexander, Schulte, Johannes H
Publicado 2013

GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma

por Zirngibl, Felix, Ivasko, Sara M, Grunewald, Laura, Klaus, Anika, Schwiebert, Silke, Ruf, Peter, Lindhofer, Horst, Astrahantseff, Kathy, Andersch, Lena, Schulte, Johannes H, Lode, Holger N, Eggert, Angelika, Anders, Kathleen, Hundsdoerfer, Patrick, Künkele, Annette
Publicado 2021

Combination of GD2-directed bispecific trifunctional antibody therapy with Pd-1 immune checkpoint blockade induces anti-neuroblastoma immunity in a syngeneic mouse model

por Ivasko, Sara Marie, Anders, Kathleen, Grunewald, Laura, Launspach, Michael, Klaus, Anika, Schwiebert, Silke, Ruf, Peter, Lindhofer, Horst, Lode, Holger N., Andersch, Lena, Schulte, Johannes H., Eggert, Angelika, Hundsdoerfer, Patrick, Künkele, Annette, Zirngibl, Felix
Publicado 2023

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing

por Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C., Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H., Künkele, Annette
Publicado 2019

CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus

por Textor, Ana, Grunewald, Laura, Anders, Kathleen, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Stecklum, Maria, Rolff, Jana, Henssen, Anton G., Höpken, Uta E., Eggert, Angelika, Schulte, Johannes H., Jensen, Michael C., Blankenstein, Thomas, Künkele, Annette
Publicado 2021

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B-cell impairment and increases the risk for infections - a retrospective matched coho...

por Launspach, Michael, Temel, Dennis, Ohlendorf, Emily, Zirngibl, Felix, Materne, Bianca, Oevermann, Lena, Deubzer, Hedwig E., Henssen, Anton G., Künkele, Annette, Hundsdörfer, Patrick, von Bernuth, Horst, Pruß, Axel, Eggert, Angelika, von Stackelberg, Arend, Lang, Peter, Schulte, Johannes H.
Publicado 2022

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4(+) CAR T Cell Efficacy

por Ali, Solin, Toews, Karin, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Grunewald, Laura, Oevermann, Lena, Deubzer, Hedwig E., Tüns, Alicia, Jensen, Michael C., Henssen, Anton G., Eggert, Angelika, Schulte, Johannes H., Schwich, Esther, Rebmann, Vera, Schramm, Alexander, Künkele, Annette
Publicado 2020

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

por Pajtler, Kristian W, Sadowski, Natalie, Ackermann, Sandra, Althoff, Kristina, Schönbeck, Kerstin, Batzke, Katharina, Sch, Simonäfers, Odersky, Andrea, Heukamp, Lukas, Astrahantseff, Kathy, Künkele, Annette, Deubzer, Hedwig E, Schramm, Alexander, Spr, Annikaüssel, Thor, Theresa, Lindner, Sven, Eggert, Angelika, Fischer, Matthias, Schulte, Johannes H
Publicado 2016