NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

por Schulz, Christian, Kammerer, Sarah, Küpper, Jan-Heiner
Publicado 2019

Effect of Prostanoids on Human Platelet Function: An Overview

por Braune, Steffen, Küpper, Jan-Heiner, Jung, Friedrich
Publicado 2020

Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone

por Schulz, Christian, Jung, Friedrich, Küpper, Jan-Heiner
Publicado 2021

Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells

por Rutz, Lukas, Gao, Lan, Küpper, Jan-Heiner, Schrenk, Dieter
Publicado 2020

Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biot...

por Schulz, Christian, Herzog, Natalie, Kubick, Stefan, Jung, Friedrich, Küpper, Jan-Heiner
Publicado 2023

Potential Effects of Nonadherent on Adherent Human Umbilical Venous Endothelial Cells in Cell Culture

por Schulz, Christian, Krüger-Genge, Anne, Lendlein, Andreas, Küpper, Jan-Heiner, Jung, Friedrich
Publicado 2021

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

por Braune, Steffen, Krüger-Genge, Anne, Kammerer, Sarah, Jung, Friedrich, Küpper, Jan-Heiner
Publicado 2021

Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery

por Haas, Manuel, Wirachowski, Karina, Thibol, Lea, Küpper, Jan-Heiner, Schrenk, Dieter, Fahrer, Jörg
Publicado 2023

OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects

por Haas, Manuel, Ackermann, Gabriel, Küpper, Jan-Heiner, Glatt, Hansruedi, Schrenk, Dieter, Fahrer, Jörg
Publicado 2023

Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells

por Abdelfatah, Sara, Naß, Janine, Knorz, Caroline, Klauck, Sabine M., Küpper, Jan-Heiner, Efferth, Thomas
Publicado 2021

Morphology and Growth of Arthrospira platensis during Cultivation in a Flat-Type Bioreactor

por Jung, Conrad H. G., Braune, Steffen, Waldeck, Peter, Küpper, Jan-Heiner, Petrick, Ingolf, Jung, Friedrich
Publicado 2021

Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines

por Lemm, Sandy, Köhler, Susanne, Wodtke, Robert, Jung, Friedrich, Küpper, Jan-Heiner, Pietzsch, Jens, Laube, Markus
Publicado 2022

The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells

por Rosellini, Matteo, Schulze, Alicia, Omer, Ejlal A., Ali, Nadeen T., Marini, Federico, Küpper, Jan-Heiner, Efferth, Thomas
Publicado 2023

Stable Expression of Human Muscle-Specific Kinase in HEp-2 M4 Cells for Automatic Immunofluorescence Diagnostics of Myasthenia Gravis

por George, Sandra, Paulick, Silvia, Knütter, Ilka, Röber, Nadja, Hiemann, Rico, Roggenbuck, Dirk, Conrad, Karsten, Küpper, Jan-Heiner
Publicado 2014

Influence of Different Light-Emitting Diode Colors on Growth and Phycobiliprotein Generation of Arthrospira platensis

por Jung, Conrad H. G., Waldeck, Peter, Sykora, Shadi, Braune, Steffen, Petrick, Ingolf, Küpper, Jan-Heiner, Jung, Friedrich
Publicado 2022

Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells

por Steinbrecht, Susanne, Kiebist, Jan, König, Rosalie, Thiessen, Markus, Schmidtke, Kai-Uwe, Kammerer, Sarah, Küpper, Jan-Heiner, Scheibner, Katrin
Publicado 2020

Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview

por Jung, Friedrich, Braune, Steffen, Jung, Conrad H. G., Krüger-Genge, Anne, Waldeck, Peter, Petrick, Ingolf, Küpper, Jan-Heiner
Publicado 2022

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

por Vagiannis, Dimitrios, Novotna, Eva, Skarka, Adam, Kammerer, Sarah, Küpper, Jan-Heiner, Chen, Si, Guo, Lei, Staud, Frantisek, Hofman, Jakub
Publicado 2020

Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors

por Gehre, Christian, Flechner, Marie, Kammerer, Sarah, Küpper, Jan-Heiner, Coleman, Charles Dominic, Püschel, Gerhard Paul, Uhlig, Katja, Duschl, Claus
Publicado 2020

Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo

por Vagiannis, Dimitrios, Budagaga, Youssif, Morell, Anselm, Zhang, Yu, Novotná, Eva, Skarka, Adam, Kammerer, Sarah, Küpper, Jan-Heiner, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub
Publicado 2021