DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β

por Nagao, Toshikage, Oshikawa, Gaku, Wu, Nan, Kurosu, Tetsuya, Miura, Osamu
Publicado 2011

PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells

por WU, NAN, KUROSU, TETSUYA, OSHIKAWA, GAKU, NAGAO, TOSHIKAGE, MIURA, OSAMU
Publicado 2012

Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhan...

por Kurosu, Tetsuya, Nagao, Toshikage, Wu, Nan, Oshikawa, Gaku, Miura, Osamu
Publicado 2013

Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells

por Umezawa, Yoshihiro, Kurosu, Tetsuya, Akiyama, Hiroki, Wu, Nang, Nogami, Ayako, Nagao, Toshikage, Miura, Osamu
Publicado 2016

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed...

por Nagao, Toshikage, Kurosu, Tetsuya, Umezawa, Yoshihiro, Nogami, Ayako, Oshikawa, Gaku, Tohda, Shuji, Yamamoto, Masahide, Miura, Osamu
Publicado 2014

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

por Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu
Publicado 2015