Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype

por Katainen, Riku, Donner, Iikki, Räisänen, Maritta, Berta, Davide, Kuosmanen, Anna, Kaasinen, Eevi, Hietala, Marja, Aaltonen, Lauri A
Publicado 2022

Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer

por Pitkänen, Esa, Cajuso, Tatiana, Katainen, Riku, Kaasinen, Eevi, Välimäki, Niko, Palin, Kimmo, Taipale, Jussi, Aaltonen, Lauri A., Kilpivaara, Outi
Publicado 2014

Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

por Taira, Aurora, Palin, Kimmo, Kuosmanen, Anna, Välimäki, Niko, Kuittinen, Outi, Kuismin, Outi, Kaasinen, Eevi, Rajamäki, Kristiina, Aaltonen, Lauri A.
Publicado 2023

Global metabolomic profiling of uterine leiomyomas

por Heinonen, Hanna-Riikka, Mehine, Miika, Mäkinen, Netta, Pasanen, Annukka, Pitkänen, Esa, Karhu, Auli, Sarvilinna, Nanna S, Sjöberg, Jari, Heikinheimo, Oskari, Bützow, Ralf, Aaltonen, Lauri A, Kaasinen, Eevi
Publicado 2017

The interaction landscape between transcription factors and the nucleosome

por Zhu, Fangjie, Farnung, Lucas, Kaasinen, Eevi, Sahu, Biswajyoti, Yin, Yimeng, Wei, Bei, Dodonova, Svetlana O., Nitta, Kazuhiro R., Morgunova, Ekaterina, Taipale, Minna, Cramer, Patrick, Taipale, Jussi
Publicado 2018

Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

por Dave, Kashyap, Sur, Inderpreet, Yan, Jian, Zhang, Jilin, Kaasinen, Eevi, Zhong, Fan, Blaas, Leander, Li, Xiaoze, Kharazi, Shabnam, Gustafsson, Charlotte, De Paepe, Ayla, Månsson, Robert, Taipale, Jussi
Publicado 2017

Sequence determinants of human gene regulatory elements

por Sahu, Biswajyoti, Hartonen, Tuomo, Pihlajamaa, Päivi, Wei, Bei, Dave, Kashyap, Zhu, Fangjie, Kaasinen, Eevi, Lidschreiber, Katja, Lidschreiber, Michael, Daub, Carsten O., Cramer, Patrick, Kivioja, Teemu, Taipale, Jussi
Publicado 2022

Nationwide Registry-Based Analysis of Cancer Clustering Detects Strong Familial Occurrence of Kaposi Sarcoma

por Kaasinen, Eevi, Aavikko, Mervi, Vahteristo, Pia, Patama, Toni, Li, Yilong, Saarinen, Silva, Kilpivaara, Outi, Pitkänen, Esa, Knekt, Paul, Laaksonen, Maarit, Artama, Miia, Lehtonen, Rainer, Aaltonen, Lauri A., Pukkala, Eero
Publicado 2013

Molecular subclass of uterine fibroids predicts tumor shrinkage in response to ulipristal acetate

por Kolterud, Åsa, Välimäki, Niko, Kuisma, Heli, Patomo, Joonatan, Ilves, Sini T, Mäkinen, Netta, Kaukomaa, Jaana, Palin, Kimmo, Kaasinen, Eevi, Karhu, Auli, Pasanen, Annukka, Bützow, Ralf, Heikinheimo, Oskari, Kopp Kallner, Helena, Aaltonen, Lauri A
Publicado 2022

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

por Välimäki, Niko, Kuisma, Heli, Pasanen, Annukka, Heikinheimo, Oskari, Sjöberg, Jari, Bützow, Ralf, Sarvilinna, Nanna, Heinonen, Hanna-Riikka, Tolvanen, Jaana, Bramante, Simona, Tanskanen, Tomas, Auvinen, Juha, Uimari, Outi, Alkodsi, Amjad, Lehtonen, Rainer, Kaasinen, Eevi, Palin, Kimmo, Aaltonen, Lauri A
Publicado 2018

Parity associates with chromosomal damage in uterine leiomyomas

por Kuisma, Heli, Bramante, Simona, Rajamäki, Kristiina, Sipilä, Lauri J., Kaasinen, Eevi, Kaukomaa, Jaana, Palin, Kimmo, Mäkinen, Netta, Sjöberg, Jari, Sarvilinna, Nanna, Taipale, Jussi, Kauppi, Liisa, Tumiati, Manuela, Hassinen, Antti, Pitkäniemi, Janne, Jalkanen, Jyrki, Heikkinen, Sanna, Pasanen, Annukka, Heikinheimo, Oskari, Bützow, Ralf, Välimäki, Niko, Aaltonen, Lauri A.
Publicado 2021

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

por Cajuso, Tatiana, Sulo, Päivi, Tanskanen, Tomas, Katainen, Riku, Taira, Aurora, Hänninen, Ulrika A., Kondelin, Johanna, Forsström, Linda, Välimäki, Niko, Aavikko, Mervi, Kaasinen, Eevi, Ristimäki, Ari, Koskensalo, Selja, Lepistö, Anna, Renkonen-Sinisalo, Laura, Seppälä, Toni, Kuopio, Teijo, Böhm, Jan, Mecklin, Jukka-Pekka, Kilpivaara, Outi, Pitkänen, Esa, Palin, Kimmo, Aaltonen, Lauri A.
Publicado 2019

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

por Aavikko, Mervi, Kaasinen, Eevi, Andersson, Noora, Pentinmikko, Nalle, Sulo, Päivi, Donner, Iikki, Pihlajamaa, Päivi, Kuosmanen, Anna, Bramante, Simona, Katainen, Riku, Sipilä, Lauri J, Martin, Samantha, Arola, Johanna, Carpén, Olli, Heiskanen, Ilkka, Mecklin, Jukka-Pekka, Taipale, Jussi, Ristimäki, Ari, Lehti, Kaisa, Gucciardo, Erika, Katajisto, Pekka, Schalin-Jäntti, Camilla, Vahteristo, Pia, Aaltonen, Lauri A
Publicado 2021

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

por Kaasinen, Eevi, Kuismin, Outi, Rajamäki, Kristiina, Ristolainen, Heikki, Aavikko, Mervi, Kondelin, Johanna, Saarinen, Silva, Berta, Davide G., Katainen, Riku, Hirvonen, Elina A. M., Karhu, Auli, Taira, Aurora, Tanskanen, Tomas, Alkodsi, Amjad, Taipale, Minna, Morgunova, Ekaterina, Franssila, Kaarle, Lehtonen, Rainer, Mäkinen, Markus, Aittomäki, Kristiina, Palotie, Aarno, Kurki, Mitja I., Pietiläinen, Olli, Hilpert, Morgane, Saarentaus, Elmo, Niinimäki, Jaakko, Junttila, Juhani, Kaikkonen, Kari, Vahteristo, Pia, Skoda, Radek C., Seppänen, Mikko R. J., Eklund, Kari K., Taipale, Jussi, Kilpivaara, Outi, Aaltonen, Lauri A.
Publicado 2019

Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

por Kondelin, Johanna, Salokas, Kari, Saarinen, Lilli, Ovaska, Kristian, Rauanheimo, Heli, Plaketti, Roosa‐Maria, Hamberg, Jiri, Liu, Xiaonan, Yadav, Leena, Gylfe, Alexandra E, Cajuso, Tatiana, Hänninen, Ulrika A, Palin, Kimmo, Ristolainen, Heikki, Katainen, Riku, Kaasinen, Eevi, Tanskanen, Tomas, Aavikko, Mervi, Taipale, Minna, Taipale, Jussi, Renkonen‐Sinisalo, Laura, Lepistö, Anna, Koskensalo, Selja, Böhm, Jan, Mecklin, Jukka‐Pekka, Ongen, Halit, Dermitzakis, Emmanouil T, Kilpivaara, Outi, Vahteristo, Pia, Turunen, Mikko, Hautaniemi, Sampsa, Tuupanen, Sari, Karhu, Auli, Välimäki, Niko, Varjosalo, Markku, Pitkänen, Esa, Aaltonen, Lauri A
Publicado 2018

Contribution of allelic imbalance to colorectal cancer

por Palin, Kimmo, Pitkänen, Esa, Turunen, Mikko, Sahu, Biswajyoti, Pihlajamaa, Päivi, Kivioja, Teemu, Kaasinen, Eevi, Välimäki, Niko, Hänninen, Ulrika A., Cajuso, Tatiana, Aavikko, Mervi, Tuupanen, Sari, Kilpivaara, Outi, van den Berg, Linda, Kondelin, Johanna, Tanskanen, Tomas, Katainen, Riku, Grau, Marta, Rauanheimo, Heli, Plaketti, Roosa-Maria, Taira, Aurora, Sulo, Päivi, Hartonen, Tuomo, Dave, Kashyap, Schmierer, Bernhard, Botla, Sandeep, Sokolova, Maria, Vähärautio, Anna, Gladysz, Kornelia, Ongen, Halit, Dermitzakis, Emmanouil, Bramsen, Jesper Bertram, Ørntoft, Torben Falck, Andersen, Claus Lindbjerg, Ristimäki, Ari, Lepistö, Anna, Renkonen-Sinisalo, Laura, Mecklin, Jukka-Pekka, Taipale, Jussi, Aaltonen, Lauri A.
Publicado 2018

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

por Orlando, Giulia, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan, Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Ko Win, Aung, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Aaltonen, Lauri A., Houlston, Richard S.
Publicado 2016

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

por May-Wilson, Sebastian, Sud, Amit, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Fisher, David, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy P., Tomlinson, Ian P., Dunlop, Malcolm G., Houlston, Richard S.
Publicado 2017

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

por Jarvis, David, Mitchell, Jonathan S, Law, Philip J, Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A, Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G, Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Meklin, Jukka-Pekka, Al-Tassan, Nada A, Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M, Timofeeva, Maria N, Meyer, Brian F, Wakil, Salma M, Campbell, Harry, Smith, Christopher G, Idziaszczyk, Shelley, Maughan, Timothy S, Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D, Win, Aung K, Hopper, John L, Jenkins, Mark A, Lindor, Noralane M, Newcomb, Polly A, Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Aaltonen, Lauri A, Cheadle, Jeremy P, Dunlop, Malcolm G, Tomlinson, Ian P, Houlston, Richard S
Publicado 2016

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

por Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J., Starr, John, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D., Win, Aung-Ko, Hopper, John, Jenkins, Mark E., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Easton, Douglas F., Pharoah, Paul D. P., Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matošević, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P., Aaltonen, Lauri A., Tomlinson, Ian, Houlston, Richard S., Dunlop, Malcolm G.
Publicado 2019