Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

por Hanse, Eric A, Ruan, Chunhai, Kachman, Maureen, Wang, Dongyu, Lowman, Xazmin H, Kelekar, Ameeta
Publicado 2017

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis

por Harfmann, Brianna D., Schroder, Elizabeth A., Kachman, Maureen T., Hodge, Brian A., Zhang, Xiping, Esser, Karyn A.
Publicado 2016

Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure

por Chaanine, Antoine H., Higgins, LeeAnn, Markowski, Todd, Harman, Jarrod, Kachman, Maureen, Burant, Charles, Navar, L. Gabriel, Busija, David, Delafontaine, Patrice
Publicado 2021

Metabolomic determinants of metabolic risk in Mexican adolescents

por Perng, Wei, Hector, Emily C., Song, Peter X.K., Rojo, Martha Maria Tellez, Raskind, Sasha, Kachman, Maureen, Cantoral, Alejandra, Burant, Charles F., Peterson, Karen E.
Publicado 2017

Comparing the Fasting and Random-Fed Metabolome Response to an Oral Glucose Tolerance Test in Children and Adolescents: Implications of Sex, Obesity, and Insulin Resistance

por LaBarre, Jennifer L., Hirschfeld, Emily, Soni, Tanu, Kachman, Maureen, Wigginton, Janis, Duren, William, Fleischman, Johanna Y., Karnovsky, Alla, Burant, Charles F., Lee, Joyce M.
Publicado 2021

DDRE-28. MECHANISTIC AND THERAPEUTIC LINKS BETWEEN PURINE BIOSYNTHESIS AND DNA DAMAGE IN GLIOBLASTOMA

por Scott, Andrew, Zhou, Weihua, Wilder-Romans, Kari, Feng, Jiane, Wu, Zhe, Andren, Anthony, Zhang, Li, Sajjakulnukit, Peter, Kachman, Maureen, Umemura, Yoshie, Schmitt, Melanie, Qi, Nathan, Lawrence, Theodore, Lyssiotis, Costas, Wahl, Daniel
Publicado 2021

DDRE-24. TARGETING PURINE METABOLISM TO OVERCOME GLIOBLASTOMA THERAPY RESISTANCE

por Zhou, Weihua, Yao, Yangyang, Scott, Andrew, Wilder-Romans, Kari, Dresser, Joseph, Werner, Christian, Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zaho, Shuang, Davis, Mary, Nelson, Barbara, Halbrook, Christopher, Zhang, Li, Gatto, Francesco, Srinivasan, Sudharsan, Jairath, Neil, Correa, Luis, Umemura, Yoshie, Walker, Angela, Kachman, Maureen, Qi, Nathan, Sarkaria, Jann, Xiong, Jianping, Morgan, Meredith, Rehemtulla, Alnawaz, Castro, Maria, Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore, Lyssiotis, Costas, Wahl, Daniel
Publicado 2021

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

por Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.
Publicado 2020

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

por Puca, Francesca, Yu, Fei, Bartolacci, Caterina, Pettazzoni, Piergiorgio, Carugo, Alessandro, Huang-Hobbs, Emmet, Liu, Jintan, Zanca, Ciro, Carbone, Federica, Del Poggetto, Edoardo, Gumin, Joy, Dasgupta, Pushan, Seth, Sahil, Srinivasan, Sanjana, Lang, Frederick F., Sulman, Erik P., Lorenzi, Philip L., Tan, Lin, Shan, Mengrou, Tolstyka, Zachary P., Kachman, Maureen, Zhang, Li, Gao, Sisi, Deem, Angela K., Genovese, Giannicola, Scaglioni, Pier Paolo, Lyssiotis, Costas A., Viale, Andrea, Draetta, Giulio F.
Publicado 2021

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

por Venneti, Sriram, Kawakibi, Abed Rahman, Ji, Sunjong, Waszak, Sebastian M., Sweha, Stefan R., Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton S., Ramage, Samuel, Chi, Andrew, Wen, Patrick Y., Arrillaga-Romany, Isabel, Batchelor, Tracy T., Butowski, Nicholas A., Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca A., de Groot, John, Mehta, Minesh, Hall, Matthew D., Daghistani, Doured, Cloughesy, Timothy F., Ellingson, Benjamin M., Beccaria, Kevin, Varlet, Pascale, Kim, Michelle M., Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Kachman, Maureen, Baum, Heidi, Burant, Charles F., Mottl, Sophie L., Cartaxo, Rodrigo T., John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Ravi, Karthik, Waugh, Alyssa, Walling, Dustin, Ding, Yujie, Xia, Ziyun, Schwendeman, Anna, Hawes, Debra, Yang, Fusheng, Judkins, Alexander R., Wahl, Daniel, Lyssiotis, Costas A., de la Nava, Daniel, Alonso, Marta M., Eze, Augustine, Spitzer, Jasper, Schmidt, Susanne V., Duchatel, Ryan J., Dun, Matthew D., Cain, Jason E., Jiang, Li, Stopka, Sylwia A., Baquer, Gerard, Regan, Michael S., Filbin, Mariella G., Agar, Nathalie Y.R., Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka N., Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam, Nazarian, Javad, Allen, Joshua E., Odia, Yazmin, Gardner, Sharon L., Koschmann, Carl
Publicado 2023