Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging

por Neuner, Sarah M., Ding, Shengyuan, Kaczorowski, Catherine C.
Publicado 2018

Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model

por Neuner, Sarah M., Heuer, Sarah E., Zhang, Ji-Gang, Philip, Vivek M., Kaczorowski, Catherine C.
Publicado 2019

Genetic background modifies CNS‐mediated sensorimotor decline in the AD‐BXD mouse model of genetic diversity in Alzheimer's disease

por O'Connell, Kristen M. S., Ouellette, Andrew R., Neuner, Sarah M., Dunn, Amy R., Kaczorowski, Catherine C.
Publicado 2019

Cell-Type-Specific Changes in Intrinsic Excitability in the Subiculum following Learning and Exposure to Novel Environmental Contexts

por Dunn, Amy R., Neuner, Sarah M., Ding, Shengyuan, Hope, Kevin A., O’Connell, Kristen M.S., Kaczorowski, Catherine C.
Publicado 2019

Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice

por Wei, Wei, Pham, Kevin, Gammons, Jesse W., Sutherland, Daniel, Liu, Yanyun, Smith, Alana, Kaczorowski, Catherine C., O’Connell, Kristen M.S.
Publicado 2015

Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes

por Ouellette, Andrew R., Hadad, Niran, Deighan, Andrew, Robinson, Laura, O’Connell, Kristen, Freund, Adam, Churchill, Gary A., Kaczorowski, Catherine C.
Publicado 2022

Genetic background influences the 5XFAD Alzheimer’s disease mouse model brain proteome

por Hurst, Cheyenne D., Dunn, Amy R., Dammer, Eric B., Duong, Duc M., Seyfried, Nicholas T., Kaczorowski, Catherine C., Johnson, Erik C. B.
Publicado 2023

Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains

por Welikovitch, Lindsay A., Dujardin, Simon, Dunn, Amy R., Fernandes, Analiese R., Khasnavis, Anita, Chibnik, Lori B., Kaczorowski, Catherine C., Hyman, Bradley T.
Publicado 2023

Multi-scale study of normal aging predicts novel late-onset Alzheimer's disease risk variants

por Neuner, Sarah M, Wilmott, Lynda, DeBoth, Matthew, Shapaker, Thomas, Ingels, Jesse, Lu, Lu, Williams, Rob, Kempermann, Gerd, Huentelman, Matthew, Kaczorowski, Catherine C
Publicado 2015

Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice

por Heuer, Sarah E., Neuner, Sarah M., Hadad, Niran, O'Connell, Kristen M.S., Williams, Robert W., Philip, Vivek M., Gaiteri, Chris, Kaczorowski, Catherine C.
Publicado 2020

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

por McQuail, Joseph A., Dunn, Amy R., Stern, Yaakov, Barnes, Carol A., Kempermann, Gerd, Rapp, Peter R., Kaczorowski, Catherine C., Foster, Thomas C.
Publicado 2021

Leveraging genetic diversity in mice to inform individual differences in brain microstructure and memory

por Murdy, Thomas J., Dunn, Amy R., Singh, Surjeet, Telpoukhovskaia, Maria A., Zhang, Shanrong, White, Jacqueline K., Kahn, Itamar, Febo, Marcelo, Kaczorowski, Catherine C.
Publicado 2023

Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome

por Hurst, Cheyenne D., Dunn, Amy R., Dammer, Eric B., Duong, Duc M., Shapley, Sarah M., Seyfried, Nicholas T., Kaczorowski, Catherine C., Johnson, Erik C. B.
Publicado 2023

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

por Korgan, Austin C., Oliveira-Abreu, Klausen, Wei, Wei, Martin, Sophie L. A., Bridges, Zoey J. D., Leal-Cardoso, José Henrique, Kaczorowski, Catherine C., O’Connell, Kristen M. S.
Publicado 2023

Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel

por Dunn, Amy R., Hadad, Niran, Neuner, Sarah M., Zhang, Ji-Gang, Philip, Vivek M., Dumitrescu, Logan, Hohman, Timothy J., Herskowitz, Jeremy H., O’Connell, Kristen M. S., Kaczorowski, Catherine C.
Publicado 2020

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

por Clayton, Terry, Poe, Michael M., Rallapalli, Sundari, Biawat, Poonam, Savić, Miroslav M., Rowlett, James K., Gallos, George, Emala, Charles W., Kaczorowski, Catherine C., Stafford, Douglas C., Arnold, Leggy A., Cook, James M.
Publicado 2015

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

por Nackenoff, Alex G., Hohman, Timothy J., Neuner, Sarah M., Akers, Carolyn S., Weitzel, Nicole C., Shostak, Alena, Ferguson, Shawn M., Mobley, Bret, Bennett, David A., Schneider, Julie A., Jefferson, Angela L., Kaczorowski, Catherine C., Schrag, Matthew S.
Publicado 2021

Identification of a Functional Non-coding Variant in the GABA(A) Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

por Mulligan, Megan K., Abreo, Timothy, Neuner, Sarah M., Parks, Cory, Watkins, Christine E., Houseal, M. Trevor, Shapaker, Thomas M., Hook, Michael, Tan, Haiyan, Wang, Xusheng, Ingels, Jesse, Peng, Junmin, Lu, Lu, Kaczorowski, Catherine C., Bryant, Camron D., Homanics, Gregg E., Williams, Robert W.
Publicado 2019

Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model

por Gurdon, Brianna, Yates, Sharon C., Csucs, Gergely, Groeneboom, Nicolaas E., Hadad, Niran, Telpoukhovskaia, Maria, Ouellette, Andrew, Ouellette, Tionna, O’Connell, Kristen, Singh, Surjeet, Murdy, Tom, Merchant, Erin, Bjerke, Ingvild, Kleven, Heidi, Schlegel, Ulrike, Leergaard, Trygve B., Puchades, Maja A., Bjaalie, Jan G., Kaczorowski, Catherine C.
Publicado 2023

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia

por Ouellette, Andrew R., Neuner, Sarah M., Dumitrescu, Logan, Anderson, Laura C., Gatti, Daniel M., Mahoney, Emily R., Bubier, Jason A., Churchill, Gary, Peters, Luanne, Huentelman, Matthew J., Herskowitz, Jeremy H., Yang, Hyun-Sik, Smith, Alexandra N., Reitz, Christiane, Kunkle, Brian W., White, Charles C., De Jager, Philip L., Schneider, Julie A., Bennett, David A., Seyfried, Nicholas T., Chesler, Elissa J., Hadad, Niran, Hohman, Timothy J., Kaczorowski, Catherine C.
Publicado 2020