A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes

por Chen, Yanyun, Song, Min, Riley, Jonathan P., Hu, Charlie C., Peng, Xianbu, Scheuner, Donalyn, Bokvist, Krister, Maiti, Pranab, Kahl, Steven D., Montrose‐Rafizadeh, Chahrzad, Hamdouchi, Chafiq, Miller, Anne Reifel
Publicado 2016

Preclinical Characterization of Once Weekly Basal Insulin Fc (BIF)

por Moyers, Julie S, Hansen, Ryan J, Day, Jonathan W, Dickinson, Craig D, Zhang, Chen, Kahl, Steven D, Ruan, Xiaoping, Ding, Liyun, Brown, Robin M, Baker, Hana E, Beals, John M
Publicado 2021

Structural basis for GPR40 allosteric agonism and incretin stimulation

por Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq
Publicado 2018

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

por Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Publicado 2018