Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

por Pérez-Revuelta, B I, Hettich, M M, Ciociaro, A, Rotermund, C, Kahle, P J, Krauss, S, Di Monte, D A
Publicado 2014

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofi...

por Ekmark-Lewén, S., Aniszewska, A., Molisak, A., Gumucio, A., Lindström, V., Kahle, P.J., Nordström, E., Möller, C., Fälting, J., Lannfelt, L., Bergström, J., Ingelsson, M.
Publicado 2023

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice

por Keane, P.C., Hanson, P.S., Patterson, L., Blain, P.G., Hepplewhite, P., Khundakar, A.A., Judge, S.J., Kahle, P.J., LeBeau, F.E.N., Morris, C.M.
Publicado 2019