Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo

por Bezman, Natalie A., Lian, Lurong, Abrams, Charles S., Brass, Lawrence F., Kahn, Mark L., Jordan, Martha S., Koretzky, Gary A.
Publicado 2008

VEGFR3 is required for button junction formation in lymphatic vessels

por Jannaway, Melanie, Iyer, Drishya, Mastrogiacomo, Diandra M., Li, Kunyu, Sung, Derek C., Yang, Ying, Kahn, Mark L., Scallan, Joshua P.
Publicado 2023

Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1(K/K) Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lu...

por Szoták-Ajtay, Kitti, Szõke, Dániel, Kovács, Gábor, Andréka, Judit, Brenner, Gábor B., Giricz, Zoltán, Penninger, Josef, Kahn, Mark L., Jakus, Zoltán
Publicado 2020

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

por Nonomura, Keiko, Lukacs, Viktor, Sweet, Daniel T., Goddard, Lauren M., Kanie, Akemi, Whitwam, Tess, Ranade, Sanjeev S., Fujimori, Toshihiko, Kahn, Mark L., Patapoutian, Ardem
Publicado 2018

Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox–Based Lineage Tracing

por Johnson, NICOLETTE M., Na, JEEYOON, Monaghan, KEARA E., Tang, ALAN T., Tian, YUHUA, Leu, NICOLAE A., Li, NING, Kahn, MARK L., Lengner, CHRISTOPHER J.
Publicado 2022

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations

por Snellings, Daniel A., Girard, Romuald, Lightle, Rhonda, Srinath, Abhinav, Romanos, Sharbel, Li, Ying, Chen, Chang, Ren, Aileen A., Kahn, Mark L., Awad, Issam A., Marchuk, Douglas A.
Publicado 2022

Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves

por Cha, Boksik, Geng, Xin, Mahamud, Md. Riaj, Fu, Jianxin, Mukherjee, Anish, Kim, Yeunhee, Jho, Eek-hoon, Kim, Tae Hoon, Kahn, Mark L., Xia, Lijun, Dixon, J. Brandon, Chen, Hong, Srinivasan, R. Sathish
Publicado 2016

Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway

por Kleaveland, Benjamin, Zheng, Xiangjian, Liu, Jian J., Blum, Yannick, Tung, Jennifer J., Zou, Zhiying, Chen, Mei, Guo, Lili, Lu, Min-min, Zhou, Diane, Kitajewski, Jan, Affolter, Markus, Ginsberg, Mark H., Kahn, Mark L.
Publicado 2009

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

por Sung, Derek C, Chen, Xiaowen, Chen, Mei, Yang, Jisheng, Schultz, Susan, Babu, Apoorva, Xu, Yitian, Gao, Siqi, Keller, TC Stevenson, Mericko-Ishizuka, Patricia, Lee, Michelle, Yang, Ying, Scallan, Joshua P, Kahn, Mark L
Publicado 2022

Lymphatic function is required prenatally for lung inflation at birth

por Jakus, Zoltán, Gleghorn, Jason P., Enis, David R., Sen, Aslihan, Chia, Stephanie, Liu, Xi, Rawnsley, David R., Yang, Yiqing, Hess, Paul R., Zou, Zhiying, Yang, Jisheng, Guttentag, Susan H., Nelson, Celeste M., Kahn, Mark L.
Publicado 2014

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice

por Gao, Siqi, Tang, Alan T., Wang, Min, Buchholz, David W., Imbiakha, Brian, Yang, Jisheng, Chen, Xiaowen, Hewins, Peter, Mericko-Ishizuka, Patricia, Leu, N. Adrian, Sterling, Stephanie, August, Avery, Jurado, Kellie A., Morrisey, Edward E., Aguilar-Carreno, Hector, Kahn, Mark L.
Publicado 2023

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

por Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L.
Publicado 2016

Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment

por Stratman, Amber N., Burns, Margaret C., Farrelly, Olivia M., Davis, Andrew E., Li, Wenling, Pham, Van N., Castranova, Daniel, Yano, Joseph J., Goddard, Lauren M., Nguyen, Oliver, Galanternik, Marina Venero, Bolan, Timothy J., Kahn, Mark L., Mukouyama, Yoh-suke, Weinstein, Brant M.
Publicado 2020

Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

por Summers, Barbara D., Kim, Kihwan, Clement, Cristina C., Khan, Zohaib, Thangaswamy, Sangeetha, McCright, Jacob, Maisel, Katharina, Zamora, Sofia, Quintero, Stephanie, Racanelli, Alexandra C., Redmond, David, D’Armiento, Jeanine, Yang, Jisheng, Kuang, Amy, Monticelli, Laurel, Kahn, Mark L., Choi, Augustine M. K., Santambrogio, Laura, Reed, Hasina Outtz
Publicado 2022

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

por Herzog, Brett H., Fu, Jianxin, Wilson, Stephen J., Hess, Paul R., Sen, Aslihan, McDaniel, J. Michael, Pan, Yanfang, Sheng, Minjia, Yago, Tadayuki, Silasi-Mansat, Robert, McGee, Samuel, May, Frauke, Nieswandt, Bernhard, Morris, Andrew J., Lupu, Florea, Coughlin, Shaun R., McEver, Rodger P., Chen, Hong, Kahn, Mark L., Xia, Lijun
Publicado 2013

Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations

por Zeineddine, Hussein A., Girard, Romuald, Saadat, Laleh, Shen, Le, Lightle, Rhonda, Moore, Thomas, Cao, Ying, Hobson, Nick, Shenkar, Robert, Avner, Kenneth, Chaudager, Kiranj, Koskimäki, Janne, Polster, Sean P., Fam, Maged D., Shi, Changbin, Lopez-Ramirez, Miguel Alejandro, Tang, Alan T., Gallione, Carol, Kahn, Mark L., Ginsberg, Mark, Marchuk, Douglas A., Awad, Issam A.
Publicado 2018

Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection

por Tang, Alan T., Buchholz, David W., Szigety, Katherine M., Imbiakha, Brian, Gao, Siqi, Frankfurter, Maxwell, Wang, Min, Yang, Jisheng, Hewins, Peter, Mericko-Ishizuka, Patricia, Leu, N Adrian, Sterling, Stephanie, Monreal, Isaac A., Sahler, Julie, August, Avery, Zhu, Xuming, Jurado, Kellie A., Xu, Mingang, Morrisey, Edward E., Millar, Sarah E., Aguilar, Hector C., Kahn, Mark L.
Publicado 2023

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

por Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.
Publicado 2020

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

por Acton, Sophie E., Astarita, Jillian L., Malhotra, Deepali, Lukacs-Kornek, Veronika, Franz, Bettina, Hess, Paul R., Jakus, Zoltan, Kuligowski, Michael, Fletcher, Anne L., Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Sceats, Lindsay, Reynoso, Erika D., Gonzalez, Santiago F., Graham, Daniel B., Chang, Jonathan, Peters, Anneli, Woodruff, Matthew, Kim, Young-A., Swat, Wojciech, Morita, Takashi, Kuchroo, Vijay, Carroll, Michael C., Kahn, Mark L., Wucherpfennig, Kai W., Turley, Shannon J.
Publicado 2012

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

por Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.
Publicado 2017