Enigma Prevents Cbl-c-Mediated Ubiquitination and Degradation of RETMEN2A

por Kales, Stephen C., Nau, Marion M., Merchant, Anand S., Lipkowitz, Stanley
Publicado 2014

Cbl-c Ubiquitin Ligase Activity Is Increased via the Interaction of Its RING Finger Domain with a LIM Domain of the Paxillin Homolog, Hic 5

por Ryan, Philip E., Kales, Stephen C., Yadavalli, Rajgopal, Nau, Marion M., Zhang, Han, Lipkowitz, Stanley
Publicado 2012

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

por Shrimp, Jonathan H., Kales, Stephen C., Sanderson, Philip E., Simeonov, Anton, Shen, Min, Hall, Matthew D.
Publicado 2020

Loss of function Cbl-c mutations in solid tumors

por Daniels, Silvano Rakeem, Liyasova, Mariya, Kales, Stephen C., Nau, Marion M., Ryan, Philip E., Green, Jeffrey E., Lipkowitz, Stanley
Publicado 2019

Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor

por Paul, Debasish, Kales, Stephen C., Cornwell, James A., Afifi, Marwa M., Rai, Ganesha, Zakharov, Alexey, Simeonov, Anton, Cappell, Steven D.
Publicado 2022

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

por Scoles, Daniel R., Gandelman, Mandi, Paul, Sharan, Dexheimer, Thomas, Dansithong, Warunee, Figueroa, Karla P., Pflieger, Lance T., Redlin, Scott, Kales, Stephen C., Sun, Hongmao, Maloney, David, Damoiseaux, Robert, Henderson, Mark J., Simeonov, Anton, Jadhav, Ajit, Pulst, Stefan M.
Publicado 2022

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

por Yan, Wenjing, Zhong, Yongwang, Hu, Xin, Xu, Tuan, Zhang, Yinghua, Kales, Stephen, Qu, Yanyan, Talley, Daniel C., Baljinnyam, Bolormaa, LeClair, Christopher A., Simeonov, Anton, Polster, Brian M., Huang, Ruili, Ye, Yihong, Rai, Ganesha, Henderson, Mark J., Tao, Dingyin, Fang, Shengyun
Publicado 2023

The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

por Gandelman, Mandi, Dansithong, Warunee, Kales, Stephen C., Paul, Sharan, Maag, Gentrie, Aoyama, Erika, Zakharov, Alexey, Rai, Ganesha, Dexheimer, Thomas, Whitehill, Brooke M., Sun, Hongmao, Jadhav, Ajit, Simeonov, Anton, Henderson, Mark J., Huynh, Duong P., Pulst, Stefan M., Scoles, Daniel R.
Publicado 2021

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

por Shrimp, Jonathan H., Janiszewski, John, Chen, Catherine Z., Xu, Miao, Wilson, Kelli M., Kales, Stephen C., Sanderson, Philip E., Shinn, Paul, Itkin, Zina, Guo, Hui, Shen, Min, Klumpp-Thomas, Carleen, Michael, Samuel G., Zheng, Wei, Simeonov, Anton, Hall, Matthew D.
Publicado 2022

CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

por Tan, Yi-Hung Carol, Krishnaswamy, Soundararajan, Nandi, Suvobroto, Kanteti, Rajani, Vora, Sapana, Onel, Kenan, Hasina, Rifat, Lo, Fang-Yi, El-Hashani, Essam, Cervantes, Gustavo, Robinson, Matthew, Kales, Stephen C., Lipkowitz, Stanley, Karrison, Theodore, Sattler, Martin, Vokes, Everett E., Wang, Yi-Ching, Salgia, Ravi
Publicado 2010

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

por Crawford, McKenna C., Tripu, Deepika R., Barritt, Samuel A., Jing, Yihang, Gallimore, Diamond, Kales, Stephen C., Bhanu, Natarajan V., Xiong, Ying, Fang, Yuhong, Butler, Kamaria A. T., LeClair, Christopher A., Coussens, Nathan P., Simeonov, Anton, Garcia, Benjamin A., Dibble, Christian C., Meier, Jordan L.
Publicado 2023

Correction: CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

por Tan, Yi-Hung Carol, Krishnaswamy, Soundararajan, Nandi, Suvobroto, Kanteti, Rajani, Vora, Sapana, Onel, Kenan, Hasina, Rifat, Lo, Fang-Yi, El-Hashani, Essam, Cervantes, Gustavo, Robinson, Matthew, Hsu, Han-Shui, Kales, Stephen C., Lipkowitz, Stanley, Karrison, Theodore, Sattler, Martin, Vokes, Everett E., Wang, Yi-Ching, Salgia, Ravi
Publicado 2011

KDM5 histone demethylases repress immune response via suppression of STING

por Wu, Lizhen, Cao, Jian, Cai, Wesley L., Lang, Sabine M., Horton, John R., Jansen, Daniel J., Liu, Zongzhi Z., Chen, Jocelyn F., Zhang, Meiling, Mott, Bryan T., Pohida, Katherine, Rai, Ganesha, Kales, Stephen C., Henderson, Mark J., Hu, Xin, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D., Cheng, Xiaodong, Shadel, Gerald S., Yan, Qin
Publicado 2018

An OpenData portal to share COVID-19 drug repurposing data in real time

por Brimacombe, Kyle R., Zhao, Tongan, Eastman, Richard T., Hu, Xin, Wang, Ke, Backus, Mark, Baljinnyam, Bolormaa, Chen, Catherine Z., Chen, Lu, Eicher, Tara, Ferrer, Marc, Fu, Ying, Gorshkov, Kirill, Guo, Hui, Hanson, Quinlin M., Itkin, Zina, Kales, Stephen C., Klumpp-Thomas, Carleen, Lee, Emily M., Michael, Sam, Mierzwa, Tim, Patt, Andrew, Pradhan, Manisha, Renn, Alex, Shinn, Paul, Shrimp, Jonathan H., Viraktamath, Amit, Wilson, Kelli M., Xu, Miao, Zakharov, Alexey V., Zhu, Wei, Zheng, Wei, Simeonov, Anton, Mathé, Ewy A., Lo, Donald C., Hall, Matthew D., Shen, Min
Publicado 2020

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

por Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Publicado 2018