Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

por Kamath, Amrita V., Iyer, Suhasini
Publicado 2014

Challenges and advances in the assessment of the disposition of antibody‐drug conjugates

por Kamath, Amrita V., Iyer, Suhasini
Publicado 2015

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

por Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita V., Crowell, Susan R.
Publicado 2021

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

por Ménochet, Karelle, Yu, Hongbin, Wang, Bonnie, Tibbitts, Jay, Hsu, Cheng-Pang, Kamath, Amrita V., Richter, Wolfgang F., Baumann, Andreas
Publicado 2022

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

por Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew
Publicado 2022

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

por Zhou, Chenguang, Cai, Hao, Baruch, Amos, Lewin-Koh, Nicholas, Yang, Meng, Guo, Fengxun, Xu, Deming, Deng, Rong, Hazenbos, Wouter, Kamath, Amrita V.
Publicado 2019

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

por Crowell, Susan R., Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M., Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V., Kelley, Robert F.
Publicado 2019

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

por Kamath, Amrita V., Williams, Simon P., Bullens, Sherry, Cowan, Kyra J., Stenberg, Yvonne, Cherry, Simon R., Rendig, Stephen, Kukis, David L., Griesemer, Chris, Damico-Beyer, Lisa A., Bunting, Stuart
Publicado 2012

Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

por Zhou, Chenguang, Lehar, Sophie, Gutierrez, Johnny, Rosenberger, Carrie M., Ljumanovic, Nina, Dinoso, Jason, Koppada, Neelima, Hong, Kyu, Baruch, Amos, Carrasco-Triguero, Montserrat, Saad, Ola, Mariathasan, Sanjeev, Kamath, Amrita V.
Publicado 2016

Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an an...

por Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R., Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G., Kamath, Amrita V.
Publicado 2018

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

por Bumbaca Yadav, Daniela, Reyes, Arthur E., Gupta, Priyanka, Vernes, Jean‐Michel, Meng, Y. Gloria, Schweiger, Michelle G., Stainton, Shannon L., Fuh, Germaine, Fielder, Paul J., Kamath, Amrita V., Shen, Ben‐Quan
Publicado 2020

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

por Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A, Khawli, Leslie, Shen, Ben-Quan
Publicado 2014

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

por Li, Chunze, Zhang, Cindy, Deng, Rong, Leipold, Douglas, Li, Dongwei, Latifi, Brandon, Gao, Yuying, Zhang, Crystal, Li, Zao, Miles, Dale, Chen, Shang‐Chiung, Samineni, Divya, Wang, Bei, Agarwal, Priya, Lu, Dan, Prabhu, Saileta, Girish, Sandhya, Kamath, Amrita V.
Publicado 2019

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent...

por Yadav, Rajbharan, Sukumaran, Siddharth, Zabka, Tanja S., Li, Jinze, Oldendorp, Amy, Morrow, Gary, Reyes, Arthur, Cheu, Melissa, Li, Jessica, Wallin, Jeffrey J., Tsai, Siao, Sun, Laura, Wang, Peiyin, Ellerman, Diego, Spiess, Christoph, Polson, Andy, Stefanich, Eric G., Kamath, Amrita V., Ovacik, Meric A.
Publicado 2022

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

por Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, Spiess, Christoph, Kamath, Amrita V.
Publicado 2018

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

por Leipold, Douglas D., Figueroa, Isabel, Masih, Shabkhaiz, Latifi, Brandon, Yip, Victor, Shen, Ben-Quan, Dere, Randall C., Carrasco-Triguero, Montserrat, Lee, M. Violet, Saad, Ola M., Liu, Luna, He, Jintang, Su, Dian, Xu, Keyang, Vuillemenot, Brian R., Laing, Steven T., Schutten, Melissa, Kozak, Katherine R., Zheng, Bing, Polson, Andrew G., Kamath, Amrita V.
Publicado 2018