LXR-Mediated Inhibition of CD4(+) T Helper Cells

por Solt, Laura A., Kamenecka, Theodore M., Burris, Thomas P.
Publicado 2012

Correction: Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

por Amador, Ariadna, Wang, Yongjun, Banerjee, Subhashis, Kamenecka, Theodore M., Solt, Laura A., Burris, Thomas P.
Publicado 2016

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

por Amador, Ariadna, Huitron-Resendiz, Salvador, Roberts, Amanda J., Kamenecka, Theodore M., Solt, Laura A., Burris, Thomas P.
Publicado 2016

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

por Frkic, Rebecca L., Marshall, Andrew C., Blayo, Anne-Laure, Pukala, Tara L., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988

por Frkic, Rebecca L., Chua, Benjamin S., Shin, Youseung, Pascal, Bruce D., Novick, Scott J., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T(H)17 driven inflammatory disorders

por Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M., Solt, Laura A.
Publicado 2021

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

por Ghoshal, Sarbani, Zhu, Qingzhang, Asteian, Alice, Lin, Hua, Xu, Haifei, Ernst, Glen, Barrow, James C., Xu, Baoji, Cameron, Michael D., Kamenecka, Theodore M., Chakraborty, Anutosh
Publicado 2016

A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors

por Radnai, Laszlo, Stremel, Rebecca F., Vaissiere, Thomas, Lin, Li, Cameron, Michael, Martin, William H., Rumbaugh, Gavin, Kamenecka, Theodore M., Griffin, Patrick R., Miller, Courtney A.
Publicado 2020

Neuron-based high-content assay and screen for CNS active mitotherapeutics

por Varkuti, Boglarka H., Kepiro, Miklos, Liu, Ze, Vick, Kyle, Avchalumov, Yosef, Pacifico, Rodrigo, MacMullen, Courtney M., Kamenecka, Theodore M., Puthanveettil, Sathyanarayanan V., Davis, Ronald L.
Publicado 2020

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

por Huang, Shuo, Liu, Chi-Hsiu, Wang, Zhongxiao, Fu, Zhongjie, Britton, William R., Blomfield, Alexandra K., Kamenecka, Theodore M., Dunaief, Joshua L., Solt, Laura A., Chen, Jing
Publicado 2022

Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization

por Liu, Chi-Hsiu, Yemanyi, Felix, Bora, Kiran, Kushwah, Neetu, Blomfield, Alexandra K., Kamenecka, Theodore M., SanGiovanni, John Paul, Sun, Ye, Solt, Laura A., Chen, Jing
Publicado 2023

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

por Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Publicado 2019

Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

por Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Publicado 2019

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

por Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.
Publicado 2019

Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands

por Choi, Jang Hyun, Banks, Alexander S., Estall, Jennifer L., Kajimura, Shingo, Bostrom, Pontus, Laznik, Dina, Ruas, Jorge L., Chalmers, Michael J., Kamenecka, Theodore M., Bluher, Matthias, Griffin, Patrick R., Spiegelman, Bruce M.
Publicado 2010

An alternate binding site for PPARγ ligands

por Hughes, Travis S., Giri, Pankaj Kumar, de Vera, Ian Mitchelle S., Marciano, David P., Kuruvilla, Dana S., Shin, Youseung, Blayo, Anne-Laure, Kamenecka, Theodore M., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2014

Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior

por Banerjee, Subhashis, Wang, Yongjun, Solt, Laura A., Griffett, Kristine, Kazantzis, Melissa, Amador, Ariadna, El-Gendy, Bahaa M., Huitron-Resendiz, Salvador, Roberts, Amanda J., Shin, Youseung, Kamenecka, Theodore M., Burris, Thomas P.
Publicado 2014

GLP-1 acts on habenular avoidance circuits to control nicotine intake

por Tuesta, Luis M., Chen, Zuxin, Duncan, Alexander, Fowler, Christie D., Ishikawa, Masago, Lee, Brian R., Liu, Xin-An, Lu, Qun, Cameron, Michael, Hayes, Matthew R., Kamenecka, Theodore M., Pletcher, Matthew, Kenny, Paul J.
Publicado 2017

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

por Deluigi, Mattia, Klipp, Alexander, Klenk, Christoph, Merklinger, Lisa, Eberle, Stefanie A., Morstein, Lena, Heine, Philipp, Mittl, Peer R. E., Ernst, Patrick, Kamenecka, Theodore M., He, Yuanjun, Vacca, Santiago, Egloff, Pascal, Honegger, Annemarie, Plückthun, Andreas
Publicado 2021

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

por Brust, Richard, Shang, Jinsai, Fuhrmann, Jakob, Mosure, Sarah A., Bass, Jared, Cano, Andrew, Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Blayo, Anne-Laure, Griffin, Patrick R., Kamenecka, Theodore M., Hughes, Travis S., Kojetin, Douglas J.
Publicado 2018