Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

por Rabe, Patrick, Kamps, Jos J. A. G., Schofield, Christopher J., Lohans, Christopher T.
Publicado 2018

The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors

por White, Mark D., Kamps, Jos J. A. G., East, Samuel, Taylor Kearney, Leah J., Flashman, Emily
Publicado 2018

(19)F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode

por Leśniak, Robert K., Rydzik, Anna M., Kamps, Jos J. A. G., Kahn, Amjad, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2019

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease

por Brewitz, Lennart, Kamps, Jos J. A. G., Lukacik, Petra, Strain‐Damerell, Claire, Zhao, Yilin, Tumber, Anthony, Malla, Tika R., Orville, Allen M., Walsh, Martin A., Schofield, Christopher J.
Publicado 2022

Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis

por Kamps, Jos J. A. G., Khan, Amjad, Choi, Hwanho, Lesniak, Robert K., Brem, Jürgen, Rydzik, Anna M., McDonough, Michael A., Schofield, Christopher J., Claridge, Timothy D. W., Mecinović, Jasmin
Publicado 2015

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

por Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin
Publicado 2015

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

por Belle, Roman, Kamps, Jos J. A. G., Poater, Jordi, Kumar, Kiran, Pieters, Bas J. G. E., Salah, Eidarus, Claridge, Timothy D. W., Paton, Robert S., Bickelhaupt, F. Matthias, Kawamura, Akane, Schofield, Christopher J., Mecinović, Jasmin
Publicado 2022

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

por Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D., Lang, Pauline A., Kamps, Jos J. A. G., Tyrrell, Jonathan M., Widlake, Emma, Saward, Benjamin G., Walsh, Timothy R., Spencer, James, Schofield, Christopher J.
Publicado 2019

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

por Pieters, Bas J. G. E., Wuts, Maud H. M., Poater, Jordi, Kumar, Kiran, White, Paul B., Kamps, Jos J. A. G., Sherman, Woody, Pruijn, Ger J. M., Paton, Robert S., Beuming, Thijs, Bickelhaupt, F. Matthias, Mecinović, Jasmin
Publicado 2020

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants

por Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Publicado 2019

The adaptability of the ion-binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF

por Lithgo, Ryan M., Hanževački, Marko, Harris, Gemma, Kamps, Jos J.A.G., Holden, Ellie, Gianga, Tiberiu-Marius, Benesch, Justin L.P., Jäger, Christof M., Croft, Anna K., Hussain, Rohannah, Hobman, Jon L., Orville, Allen M., Quigley, Andrew, Carr, Stephen B., Scott, David J.
Publicado 2023

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

por Zhang, Dong, Markoulides, Marios S., Stepanovs, Dmitrijs, Rydzik, Anna M., El-Hussein, Ahmed, Bon, Corentin, Kamps, Jos J.A.G., Umland, Klaus-Daniel, Collins, Patrick M., Cahill, Samuel T., Wang, David Y., von Delft, Frank, Brem, Jürgen, McDonough, Michael A., Schofield, Christopher J.
Publicado 2018

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

por Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.
Publicado 2021

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

por Rabe, Patrick, Kamps, Jos J. A. G., Sutherlin, Kyle D., Linyard, James D. S., Aller, Pierre, Pham, Cindy C., Makita, Hiroki, Clifton, Ian, McDonough, Michael A., Leissing, Thomas M., Shutin, Denis, Lang, Pauline A., Butryn, Agata, Brem, Jürgen, Gul, Sheraz, Fuller, Franklin D., Kim, In-Sik, Cheah, Mun Hon, Fransson, Thomas, Bhowmick, Asmit, Young, Iris D., O’Riordan, Lee, Brewster, Aaron S., Pettinati, Ilaria, Doyle, Margaret, Joti, Yasumasa, Owada, Shigeki, Tono, Kensuke, Batyuk, Alexander, Hunter, Mark S., Alonso-Mori, Roberto, Bergmann, Uwe, Owen, Robin L., Sauter, Nicholas K., Claridge, Timothy D. W., Robinson, Carol V., Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M., Schofield, Christopher J.
Publicado 2021