Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment

por Wong, Alex, Chen, Sixun, Yang, Lay Kien, Kanagasundaram, Yoganathan, Crasta, Karen
Publicado 2018

Diversity and Biosynthetic Potential of Fungi Isolated from St. John’s Island, Singapore

por Munusamy, Madhaiyan, Tan, Kenneth, Nge, Choy Eng, Gakuubi, Martin Muthee, Crasta, Sharon, Kanagasundaram, Yoganathan, Ng, Siew Bee
Publicado 2023

Enhancing the Discovery of Bioactive Secondary Metabolites From Fungal Endophytes Using Chemical Elicitation and Variation of Fermentation Media

por Gakuubi, Martin Muthee, Ching, Kuan Chieh, Munusamy, Madhaiyan, Wibowo, Mario, Liang, Zhao-Xun, Kanagasundaram, Yoganathan, Ng, Siew Bee
Publicado 2022

Transcriptomic and metabolomic characterization of antibacterial activity of Melastoma dodecandrum

por Poh, Wee Han, Ruhazat, Nur Syahirah, Yang, Lay Kien, Shivhare, Devendra, Lim, Peng Ken, Kanagasundaram, Yoganathan, Rice, Scott A., Mutwil, Marek
Publicado 2023

Isolation and Identification of an Anthracimycin Analogue from Nocardiopsis kunsanensis, a Halophile from a Saltern, by Genomic Mining Strategy

por Sirota, Fernanda L., Goh, Falicia, Low, Kia-Ngee, Yang, Lay-Kien, Crasta, Sharon C., Eisenhaber, Birgit, Eisenhaber, Frank, Kanagasundaram, Yoganathan, Ng, Siew Bee
Publicado 2018

In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation

por Thappeta, Kishore Reddy Venkata, Zhao, Li Na, Nge, Choy Eng, Crasta, Sharon, Leong, Chung Yan, Ng, Veronica, Kanagasundaram, Yoganathan, Fan, Hao, Ng, Siew Bee
Publicado 2020

CRISPR/Cas9 RNP-assisted validation of palmarumycin biosynthetic gene cluster in Lophiotrema sp. F6932

por Gakuubi, Martin Muthee, Ching, Kuan Chieh, Munusamy, Madhaiyan, Wibowo, Mario, Lim, Chun Teck, Ma, Guang-Lei, Liang, Zhao-Xun, Kanagasundaram, Yoganathan, Ng, Siew Bee
Publicado 2022

Chemical elicitation as an avenue for discovery of bioactive compounds from fungal endophytes

por Munusamy, Madhaiyan, Ching, Kuan Chieh, Yang, Lay Kien, Crasta, Sharon, Gakuubi, Martin Muthee, Chee, Zhao Yan, Wibowo, Mario, Leong, Chung Yan, Kanagasundaram, Yoganathan, Ng, Siew Bee
Publicado 2022

Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae

por Goh, Corinna Jie Hui, Cui, Liang, Wong, Jin Huei, Lewis, Jacqueline, Goh, Megan, Kong, Kiat Whye, Yang, Lay Kien, Alfatah, Mohammad, Kanagasundaram, Yoganathan, Hoon, Shawn, Arumugam, Prakash
Publicado 2022

Antibacterial Spirotetronate Polyketides from an Actinomadura sp. Strain A30804

por Ching, Kuan-Chieh, Chin, Elaine J., Wibowo, Mario, Tan, Zann Y., Yang, Lay-Kien, Seow, Deborah C., Leong, Chung-Yan, Ng, Veronica W., Ng, Siew-Bee, Kanagasundaram, Yoganathan
Publicado 2022

Antibacterial Thiopeptide GE2270-Congeners from Nonomuraea jiangxiensis

por Ching, Kuan-Chieh, Chin, Elaine J., Wibowo, Mario, Tan, Zann Y., Yang, Lay-Kien, Seow, Deborah C., Leong, Chung-Yan, Ng, Veronica W., Ng, Siew-Bee, Kanagasundaram, Yoganathan
Publicado 2022

Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities

por Chin, Elaine-Jinfeng, Ching, Kuan-Chieh, Tan, Zann Y., Wibowo, Mario, Leong, Chung-Yan, Yang, Lay-Kien, Ng, Veronica W. P., Seow, Deborah C. S., Kanagasundaram, Yoganathan, Ng, Siew-Bee
Publicado 2023

Identification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a Streptomyces strain isolated from mangrove sediment

por Low, Zhen Jie, Pang, Li Mei, Ding, Yichen, Cheang, Qing Wei, Le Mai Hoang, Kim, Thi Tran, Hoa, Li, Jinming, Liu, Xue-Wei, Kanagasundaram, Yoganathan, Yang, Liang, Liang, Zhao-Xun
Publicado 2018

Hypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells

por Alfatah, Mohammad, Wong, Jin Huei, Nge, Choy Eng, Kong, Kiat Whye, Low, Kia Ngee, Leong, Chung Yan, Crasta, Sharon, Munusamy, Madhaiyan, Chang, Amanda Mun Leng, Hoon, Shawn, Ng, Siew Bee, Kanagasundaram, Yoganathan, Arumugam, Prakash
Publicado 2019

Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723

por Sinha, Swati, Nge, Choy-Eng, Leong, Chung Yan, Ng, Veronica, Crasta, Sharon, Alfatah, Mohammad, Goh, Falicia, Low, Kia-Ngee, Zhang, Huibin, Arumugam, Prakash, Lezhava, Alexander, Chen, Swaine L., Kanagasundaram, Yoganathan, Ng, Siew Bee, Eisenhaber, Frank, Eisenhaber, Birgit
Publicado 2019

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

por Niska-Blakie, Joanna, Gopinathan, Lakshmi, Low, Kia Ngee, Kien, Yang Lay, Goh, Christine M. F., Caldez, Matias J., Pfeiffenberger, Elisabeth, Jones, Oliver S., Ong, Chee Bing, Kurochkin, Igor V., Coppola, Vincenzo, Tessarollo, Lino, Choi, Hyungwon, Kanagasundaram, Yoganathan, Eisenhaber, Frank, Maurer-Stroh, Sebastian, Kaldis, Philipp
Publicado 2019

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

por Goh, Falicia, Zhang, Mingzi M., Lim, Tian Ru, Low, Kia Ngee, Nge, Choy Eng, Heng, Elena, Yeo, Wan Lin, Sirota, Fernanda L., Crasta, Sharon, Tan, Zann, Ng, Veronica, Leong, Chung Yan, Zhang, Huibin, Lezhava, Alexander, Chen, Swaine L., Hoon, Shawn S., Eisenhaber, Frank, Eisenhaber, Birgit, Kanagasundaram, Yoganathan, Wong, Fong T., Ng, Siew Bee
Publicado 2020