Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes

por Xu, Xie L, Kapoun, Ann M
Publicado 2009

A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors

por Smith, David C., Chugh, Rashmi, Patnaik, Amita, Papadopoulos, Kyriakos P., Wang, Min, Kapoun, Ann M., Xu, Lu, Dupont, Jakob, Stagg, Robert J., Tolcher, Anthony
Publicado 2018

A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic...

por Davis, S. Lindsey, Cardin, Dana B., Shahda, Safi, Lenz, Heinz-Josef, Dotan, Efrat, O’Neil, Bert H., Kapoun, Ann M., Stagg, Robert J., Berlin, Jordan, Messersmith, Wells A., Cohen, Steven J.
Publicado 2019

WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

por Fischer, Marcus M., Cancilla, Belinda, Yeung, V. Pete, Cattaruzza, Fiore, Chartier, Cecile, Murriel, Christopher L., Cain, Jennifer, Tam, Raymond, Cheng, Chieh-Yang, Evans, James W., O’Young, Gilbert, Song, Xiaomei, Lewicki, John, Kapoun, Ann M., Gurney, Austin, Yen, Wan-Ching, Hoey, Timothy
Publicado 2017

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Res...

por Ferrarotto, Renata, Mitani, Yoshitsugu, Diao, Lixia, Guijarro, Irene, Wang, Jing, Zweidler-McKay, Patrick, Bell, Diana, William, William N., Glisson, Bonnie S., Wick, Michael J., Kapoun, Ann M., Patnaik, Amita, Eckhardt, Gail, Munster, Pamela, Faoro, Leonardo, Dupont, Jakob, Lee, J. Jack, Futreal, Andrew, El-Naggar, Adel K., Heymach, John V.
Publicado 2017

Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer

por Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien
Publicado 2017

Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs

por Zhang, Mingjun, Haughey, Michael, Wang, Nai-Yu, Blease, Kate, Kapoun, Ann M., Couto, Suzana, Belka, Igor, Hoey, Timothy, Groza, Matthew, Hartke, James, Bennett, Brydon, Cain, Jennifer, Gurney, Austin, Benish, Brent, Castiglioni, Paola, Drew, Clifton, Lachowicz, Jean, Carayannopoulos, Leon, Nathan, Steven D., Distler, Jorg, Brenner, David A., Hariharan, Kandasamy, Cho, Ho, Xie, Weilin
Publicado 2020

A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer

por Hu, Zishuo Ian, Bendell, Johanna C., Bullock, Andrea, LoConte, Noelle K., Hatoum, Hassan, Ritch, Paul, Hool, Hugo, Leach, Joseph W., Sanchez, James, Sohal, Davendra P. S., Strickler, John, Patel, Ravindranath, Wang‐Gillam, Andrea, Firdaus, Irfan, Yu, Kenneth H., Kapoun, Ann M., Holmgren, Eric, Zhou, Lei, Dupont, Jakob, Picozzi, Vincent, Sahai, Vaibhav, O'Reilly, Eileen M.
Publicado 2019