Druggable Protein Interaction Sites Are More Predisposed to Surface Pocket Formation than the Rest of the Protein Surface

por Johnson, David K., Karanicolas, John
Publicado 2013

Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations

por Johnson, David K., Karanicolas, John
Publicado 2015

Atomic accuracy in predicting and designing non-canonical RNA structure

por Das, Rhiju, Karanicolas, John, Baker, David
Publicado 2010

DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction Sites

por Gowthaman, Ragul, Lyskov, Sergey, Karanicolas, John
Publicado 2015

Fast Docking on Graphics Processing Units via Ray-Casting

por Khar, Karen R., Goldschmidt, Lukasz, Karanicolas, John
Publicado 2013

Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions

por Bazzoli, Andrea, Kelow, Simon P., Karanicolas, John
Publicado 2015

Poor Generalization by Current Deep Learning Models for Predicting Binding Affinities of Kinase Inhibitors

por Ong, Wern Juin Gabriel, Kirubakaran, Palani, Karanicolas, John
Publicado 2023

Isothermal Analysis of ThermoFluor Data can readily provide Quantitative Binding Affinities

por Bai, Nan, Roder, Heinrich, Dickson, Alex, Karanicolas, John
Publicado 2019

Computational Design of an Allosteric Antibody Switch by Deletion and Rescue of a Complex Structural Constellation

por Khowsathit, Jittasak, Bazzoli, Andrea, Cheng, Hong, Karanicolas, John
Publicado 2020

Machine learning classification can reduce false positives in structure-based virtual screening

por Adeshina, Yusuf O., Deeds, Eric J., Karanicolas, John
Publicado 2020

A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

por Ruggiero, Melissa J., Malhotra, Shipra, Fenton, Aron W., Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno
Publicado 2020

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP)

por Ruggiero, Melissa J., Malhotra, Shipra, Fenton, Aron W., Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno
Publicado 2022

Identification of novel small molecule Beclin 1 mimetics activating autophagy

por Yu, Jia, Lan, Lan, Lewin, Seth J., Rogers, Steven A., Roy, Anuradha, Wu, Xiaoqing, Gao, Philip, Karanicolas, John, Aubé, Jeffrey, Sun, Baiwang, Xu, Liang
Publicado 2017

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

por Kaur, Kawaljit, Wu, Xiaoqing, Fields, James K., Johnson, David K., Lan, Lan, Pratt, Miranda, Somoza, Amber D., Wang, Clay C. C., Karanicolas, John, Oakley, Berl R., Xu, Liang, De Guzman, Roberto N.
Publicado 2017

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

por Karmakar, Shilpita, Ramirez, Oscar, Paul, Kiran V, Gupta, Abhishek K, Kumari, Vandana, Botti, Valentina, de los Mozos, Igor Ruiz, Neuenkirchen, Nils, Ross, Robert J, Karanicolas, John, Neugebauer, Karla M, Pillai, Manoj M
Publicado 2022

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

por Bai, Nan, Adeshina, Yusuf, Bychkov, Igor, Xia, Yan, Gowthaman, Ragul, Miller, Sven A., Gupta, Abhishek K., Johnson, David K., Lan, Lan, Golemis, Erica A., Makhov, Petr B., Xu, Liang, Pillai, Manoj M., Boumber, Yanis, Karanicolas, John
Publicado 2023

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

por Bai, Nan, Adeshina, Yusuf, Bychkov, Igor, Xia, Yan, Gowthaman, Ragul, Miller, Sven A., Gupta, Abhishek K., Johnson, David K., Lan, Lan, Golemis, Erica A., Makhov, Petr B., Xu, Liang, Pillai, Manoj M., Boumber, Yanis, Karanicolas, John
Publicado 2023

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

por Lan, Lan, Liu, Hao, Smith, Amber R., Appelman, Carl, Yu, Jia, Larsen, Sarah, Marquez, Rebecca T., Wu, Xiaoqing, Liu, Frank Y., Gao, Philip, Gowthaman, Ragul, Karanicolas, John, De Guzman, Roberto N., Rogers, Steven, Aubé, Jeffrey, Neufeld, Kristi L., Xu, Liang
Publicado 2018

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

por Wu, Xiaoqing, Gardashova, Gulhumay, Lan, Lan, Han, Shuang, Zhong, Cuncong, Marquez, Rebecca T., Wei, Lanjing, Wood, Spencer, Roy, Sudeshna, Gowthaman, Ragul, Karanicolas, John, Gao, Fei P., Dixon, Dan A., Welch, Danny R., Li, Ling, Ji, Min, Aubé, Jeffrey, Xu, Liang
Publicado 2020

Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

por Lan, Lan, Liu, Jiajun, Xing, Minli, Smith, Amber R., Wang, Jinan, Wu, Xiaoqing, Appelman, Carl, Li, Ke, Roy, Anuradha, Gowthaman, Ragul, Karanicolas, John, Somoza, Amber D., Wang, Clay C. C., Miao, Yinglong, De Guzman, Roberto, Oakley, Berl R., Neufeld, Kristi L., Xu, Liang
Publicado 2020