Embedding Dynamics in Intrinsic Physicochemical Profiles of Market-Stage Antibody-Based Biotherapeutics

por Licari, Giuseppe, Martin, Kyle P., Crames, Maureen, Mozdzierz, Joseph, Marlow, Michael S., Karow-Zwick, Anne R., Kumar, Sandeep, Bauer, Joschka
Publicado 2022

Adaption of human antibody λ and κ light chain architectures to CDR repertoires

por van der Kant, Rob, Bauer, Joschka, Karow-Zwick, Anne R, Kube, Sebastian, Garidel, Patrick, Blech, Michaela, Rousseau, Frederic, Schymkowitz, Joost
Publicado 2019

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

por Bauer, Joschka, Mathias, Sven, Kube, Sebastian, Otte, Kerstin, Garidel, Patrick, Gamer, Martin, Blech, Michaela, Fischer, Simon, Karow-Zwick, Anne R
Publicado 2020

Prediction and Reduction of the Aggregation of Monoclonal Antibodies

por van der Kant, Rob, Karow-Zwick, Anne R., Van Durme, Joost, Blech, Michaela, Gallardo, Rodrigo, Seeliger, Daniel, Aßfalg, Kerstin, Baatsen, Pieter, Compernolle, Griet, Gils, Ann, Studts, Joey M., Schulz, Patrick, Garidel, Patrick, Schymkowitz, Joost, Rousseau, Frederic
Publicado 2017