Identification of benzazole compounds that induce HIV-1 transcription

por Graci, Jason D., Michaels, Daniel, Chen, Guangming, Schiralli Lester, Gillian M., Nodder, Sarah, Weetall, Marla, Karp, Gary M., Gu, Zhengxian, Colacino, Joseph M., Henderson, Andrew J.
Publicado 2017

Ribonucleotide reductase, a novel drug target for gonorrhea

por Narasimhan, Jana, Letinski, Suzanne, Jung, Stephen P, Gerasyuto, Aleksey, Wang, Jiashi, Arnold, Michael, Chen, Guangming, Hedrick, Jean, Dumble, Melissa, Ravichandran, Kanchana, Levitz, Talya, Cui, Chang, Drennan, Catherine L, Stubbe, JoAnne, Karp, Gary, Branstrom, Arthur
Publicado 2022

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria

por Gerasyuto, Aleksey I., Arnold, Michael A., Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A., Prasad, J. V. N., Karp, Gary M.
Publicado 2018

Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria

por Gerasyuto, Aleksey I., Arnold, Michael A., Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A., Prasad, J. V. N., Karp, Gary M.
Publicado 2018

Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy

por Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Mollin, Anna, Sheedy, Josephine, Yeh, Shirley, Petruska, Janet, Narasimhan, Jana, Dakka, Amal, Welch, Ellen M., Karp, Gary, Chen, Karen S., Metzger, Friedrich, Ratni, Hasane, Lotti, Francesco, Tisdale, Sarah, Naryshkin, Nikolai A., Pellizzoni, Livio, Paushkin, Sergey, Ko, Chien-Ping, Weetall, Marla
Publicado 2016

A deep learning approach to identify gene targets of a therapeutic for human splicing disorders

por Gao, Dadi, Morini, Elisabetta, Salani, Monica, Krauson, Aram J., Chekuri, Anil, Sharma, Neeraj, Ragavendran, Ashok, Erdin, Serkan, Logan, Emily M., Li, Wencheng, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Naryshkin, Nikolai, Trotta, Christopher R., Effenberger, Kerstin A., Woll, Matthew G., Gabbeta, Vijayalakshmi, Karp, Gary, Yu, Yong, Johnson, Graham, Paquette, William D., Cutting, Garry R., Talkowski, Michael E., Slaugenhaupt, Susan A.
Publicado 2021

Small molecule splicing modifiers with systemic HTT-lowering activity

por Bhattacharyya, Anuradha, Trotta, Christopher R., Narasimhan, Jana, Wiedinger, Kari J., Li, Wencheng, Effenberger, Kerstin A., Woll, Matthew G., Jani, Minakshi B., Risher, Nicole, Yeh, Shirley, Cheng, Yaofeng, Sydorenko, Nadiya, Moon, Young-Choon, Karp, Gary M., Weetall, Marla, Dakka, Amal, Gabbeta, Vijayalakshmi, Naryshkin, Nikolai A., Graci, Jason D., Tripodi, Thomas, Southwell, Amber, Hayden, Michael, Colacino, Joseph M., Peltz, Stuart W.
Publicado 2021