Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration

por Sleiman, Sama F., Berlin, Jill, Basso, Manuela, S.Karuppagounder, Saravanan, Rohr, Jürgen, Ratan, Rajiv R.
Publicado 2011

A STING agonist preconditions against ischaemic stroke via an adaptive antiviral Type 1 interferon response

por Kundu, Nandini, Kumar, Amit, Corona, Carlo, Chen, Yingxin, Seth, Sonia, Karuppagounder, Saravanan S., Ratan, Rajiv R.
Publicado 2022

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson’s disease

por Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.
Publicado 2020

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors

por Zille, Marietta, Kumar, Amit, Kundu, Nandini, Bourassa, Megan W., Wong, Victor S. C., Willis, Dianna, Karuppagounder, Saravanan S., Ratan, Rajiv R.
Publicado 2019

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

por Wei, George Z., Saraswat Ohri, Sujata, Khattar, Nicolas K., Listerman, Adam W., Doyle, Catherine H., Andres, Kariena R., Karuppagounder, Saravanan S., Ratan, Rajiv R., Whittemore, Scott R., Hetman, Michal
Publicado 2021

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

por Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V
Publicado 2016

HIF1α stabilization in hypoxia is not oxidant-initiated

por Kumar, Amit, Vaish, Manisha, Karuppagounder, Saravanan S, Gazaryan, Irina, Cave, John W, Starkov, Anatoly A, Anderson, Elizabeth T, Zhang, Sheng, Pinto, John T, Rountree, Austin M, Wang, Wang, Sweet, Ian R, Ratan, Rajiv R
Publicado 2021

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease

por Smirnova, Natalya A., Kaidery, Navneet Ammal, Hushpulian, Dmitry M., Rakhman, Ilay I., Poloznikov, Andrey A., Tishkov, Vladimir I., Karuppagounder, Saravanan S., Gaisina, Irina N., Pekcec, Anton, Leyen, Klaus Van, Kazakov, Sergey V., Yang, Lichuan, Thomas, Bobby, Ratan, Rajiv R., Gazaryan, Irina G.
Publicado 2016

N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in...

por Karuppagounder, Saravanan S., Alin, Lauren, Chen, Yingxin, Brand, David, Bourassa, Megan W., Dietrich, Kristen, Wilkinson, Cassandra M., Nadeau, Colby A., Kumar, Amit, Perry, Steve, Pinto, John T., Darley‐Usmar, Victor, Sanchez, Stephanie, Milne, Ginger L., Pratico, Domenico, Holman, Theodore R., Carmichael, S. Thomas, Coppola, Giovanni, Colbourne, Frederick, Ratan, Rajiv R.
Publicado 2018

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

por Boltze, Johannes, Aronowski, Jaroslaw A., Badaut, Jerome, Buckwalter, Marion S., Caleo, Mateo, Chopp, Michael, Dave, Kunjan R., Didwischus, Nadine, Dijkhuizen, Rick M., Doeppner, Thorsten R., Dreier, Jens P., Fouad, Karim, Gelderblom, Mathias, Gertz, Karen, Golubczyk, Dominika, Gregson, Barbara A., Hamel, Edith, Hanley, Daniel F., Härtig, Wolfgang, Hummel, Friedhelm C., Ikhsan, Maulana, Janowski, Miroslaw, Jolkkonen, Jukka, Karuppagounder, Saravanan S., Keep, Richard F., Koerte, Inga K., Kokaia, Zaal, Li, Peiying, Liu, Fudong, Lizasoain, Ignacio, Ludewig, Peter, Metz, Gerlinde A. S., Montagne, Axel, Obenaus, Andre, Palumbo, Alex, Pearl, Monica, Perez-Pinzon, Miguel, Planas, Anna M., Plesnila, Nikolaus, Raval, Ami P., Rueger, Maria A., Sansing, Lauren H., Sohrabji, Farida, Stagg, Charlotte J., Stetler, R. Anne, Stowe, Ann M., Sun, Dandan, Taguchi, Akihiko, Tanter, Mickael, Vay, Sabine U., Vemuganti, Raghu, Vivien, Denis, Walczak, Piotr, Wang, Jian, Xiong, Ye, Zille, Marietta
Publicado 2021