Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer

por Kaserer, Teresa, Blagg, Julian
Publicado 2018

Protocol for predicting drug-resistant protein mutations to an ERK2 inhibitor using RESISTOR

por Guerin, Nathan, Kaserer, Teresa, Donald, Bruce R.
Publicado 2023

μ Opioid receptor: novel antagonists and structural modeling

por Kaserer, Teresa, Lantero, Aquilino, Schmidhammer, Helmut, Spetea, Mariana, Schuster, Daniela
Publicado 2016

De novo CACAN1D Ca(2+) channelopathies: clinical phenotypes and molecular mechanism

por Ortner, Nadine J., Kaserer, Teresa, Copeland, J. Nathan, Striessnig, Jörg
Publicado 2020

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

por Kaserer, Teresa, Beck, Katharina R., Akram, Muhammad, Odermatt, Alex, Schuster, Daniela
Publicado 2015

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2

por Kaserer, Teresa, Temml, Veronika, Kutil, Zsofia, Vanek, Tomas, Landa, Premysl, Schuster, Daniela
Publicado 2015

Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions

por Kugler, Valentina, Lieb, Andreas, Guerin, Nathan, Donald, Bruce R., Stefan, Eduard, Kaserer, Teresa
Publicado 2023

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

por Lieb, Andreas, Thaler, Germana, Fogli, Barbara, Trovato, Olga, Posch, Mitja Amon, Kaserer, Teresa, Zangrandi, Luca
Publicado 2021

Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

por Kaserer, Teresa, Steinacher, Theresa, Kainhofer, Roman, Erli, Filippo, Sturm, Sonja, Waltenberger, Birgit, Schuster, Daniela, Spetea, Mariana
Publicado 2020

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases

por Engeli, Roger T., Rohrer, Simona R., Vuorinen, Anna, Herdlinger, Sonja, Kaserer, Teresa, Leugger, Susanne, Schuster, Daniela, Odermatt, Alex
Publicado 2017

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

por Liu, Manjuan, Mallinger, Aurélie, Tortorici, Marcello, Newbatt, Yvette, Richards, Meirion, Mirza, Amin, van Montfort, Rob L. M., Burke, Rosemary, Blagg, Julian, Kaserer, Teresa
Publicado 2018

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

por Hagenbuchner, Judith, Obsilova, Veronika, Kaserer, Teresa, Kaiser, Nora, Rass, Bettina, Psenakova, Katarina, Docekal, Vojtech, Alblova, Miroslava, Kohoutova, Klara, Schuster, Daniela, Aneichyk, Tatsiana, Vesely, Jan, Obexer, Petra, Obsil, Tomas, Ausserlechner, Michael J
Publicado 2019

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

por Weston, Mikail, Kaserer, Teresa, Wu, Angela, Mouravlev, Alexandre, Carpenter, Jenna C., Snowball, Albert, Knauss, Samuel, von Schimmelmann, Melanie, During, Matthew J., Lignani, Gabriele, Schorge, Stephanie, Young, Deborah, Kullmann, Dimitri M., Lieb, Andreas
Publicado 2019

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

por Salcher, Stefan, Spoden, Gilles, Hagenbuchner, Judith, Führer, Sebastian, Kaserer, Teresa, Tollinger, Martin, Huber-Cantonati, Petra, Gruber, Thomas, Schuster, Daniela, Gust, Ronald, Zwierzina, Heinz, Müller, Thomas, Kiechl-Kohlendorfer, Ursula, Ausserlechner, Michael J., Obexer, Petra
Publicado 2019

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

por Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor
Publicado 2020

A comprehensive study of SARS-CoV-2 main protease (M(pro)) inhibitor-resistant mutants selected in a VSV-based system

por Costacurta, Francesco, Dodaro, Andrea, Bante, David, Schöppe, Helge, Sprenger, Bernhard, Moghadasi, Seyed Arad, Fleischmann, Jakob, Pavan, Matteo, Bassani, Davide, Menin, Silvia, Rauch, Stefanie, Krismer, Laura, Sauerwein, Anna, Heberle, Anne, Rabensteiner, Toni, Ho, Joses, Harris, Reuben S., Stefan, Eduard, Schneider, Rainer, Kaserer, Teresa, Moro, Stefano, von Laer, Dorothee, Heilmann, Emmanuel
Publicado 2023

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

por Austin, Mark, Burschowsky, Daniel, Chan, Denice T.Y., Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Hadjinicolaou, Andreas V., Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M., Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Publicado 2020

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder

por Calpena, Eduardo, Hervieu, Alexia, Kaserer, Teresa, Swagemakers, Sigrid M.A., Goos, Jacqueline A.C., Popoola, Olajumoke, Ortiz-Ruiz, Maria Jesus, Barbaro-Dieber, Tina, Bownass, Lucy, Brilstra, Eva H., Brimble, Elise, Foulds, Nicola, Grebe, Theresa A., Harder, Aster V.E., Lees, Melissa M., Monaghan, Kristin G., Newbury-Ecob, Ruth A., Ong, Kai-Ren, Osio, Deborah, Reynoso Santos, Francis Jeshira, Ruzhnikov, Maura R.Z., Telegrafi, Aida, van Binsbergen, Ellen, van Dooren, Marieke F., van der Spek, Peter J., Blagg, Julian, Twigg, Stephen R.F., Mathijssen, Irene M.J., Clarke, Paul A., Wilkie, Andrew O.M.
Publicado 2019