Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration

por Kashyap, Trinayan, Germain, Emily, Roche, Michael, Lyle, Stephen, Rabinovitz, Isaac
Publicado 2011

A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to...

por Cass, Michael, McDonald, Andrew B., Ben-Shahar, Osnat, Landesman, Yosef, Kashyap, Trinayan
Publicado 2022

Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3

por Soung, Young Hwa, Kashyap, Trinayan, Nguyen, Thalia, Yadav, Garima, Chang, Hua, Landesman, Yosef, Chung, Jun
Publicado 2017

HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs

por Huynh, Mailee, Chang, Hae Yeun, Lisiero, Dominique N., Ong, Irene M., Kashyap, Trinayan, Callander, Natalie S., Miyamoto, Shigeki
Publicado 2022

Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

por Crochiere, Marsha, Kashyap, Trinayan, Kalid, Ori, Shechter, Sharon, Klebanov, Boris, Senapedis, William, Saint-Martin, Jean-Richard, Landesman, Yosef
Publicado 2015

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

por Walker, Christopher J., Chang, Hua, Henegar, Leah, Kashyap, Trinayan, Shacham, Sharon, Sommer, Josh, Wick, Michael J., Levy, Joan, Landesman, Yosef
Publicado 2022

Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death

por Argueta, Christian, Kashyap, Trinayan, Klebanov, Boris, Unger, Thaddeus J., Guo, Cathy, Harrington, Susie, Baloglu, Erkan, Lee, Margaret, Senapedis, William, Shacham, Sharon, Landesman, Yosef
Publicado 2018

Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

por Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L., Lee, Margaret S., Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Publicado 2018

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

por Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef
Publicado 2021

Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines

por Breit, Megan N, Kisseberth, William C, Bear, Misty D, Landesman, Yosef, Kashyap, Trinayan, McCauley, Dilara, Kauffman, Michael G, Shacham, Sharon, London, Cheryl A
Publicado 2014

Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells

por Uddin, Md. Hafiz, Li, Yiwei, Khan, Husain Yar, Muqbil, Irfana, Aboukameel, Amro, Sexton, Rachel E., Reddy, Shriya, Landesman, Yosef, Kashyap, Trinayan, Azmi, Asfar S., Heath, Elisabeth I.
Publicado 2021

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myel...

por Turner, Joel G., Kashyap, Trinayan, Dawson, Jana L., Gomez, Juan, Bauer, Alexis A., Grant, Steven, Dai, Yun, Shain, Kenneth H., Meads, Mark, Landesman, Yosef, Sullivan, Daniel M.
Publicado 2016

Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells

por Yang, Jennifer, Bill, Matthew A., Young, Gregory S., La Perle, Krista, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Senapedis, William, Kashyap, Trinayan, Saint-Martin, Jean-Richard, Kendra, Kari, Lesinski, Gregory B.
Publicado 2014

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell dea...

por Kashyap, Trinayan, Argueta, Christian, Aboukameel, Amro, Unger, Thaddeus John, Klebanov, Boris, Mohammad, Ramzi M., Muqbil, Irfana, Azmi, Asfar S., Drolen, Claire, Senapedis, William, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Publicado 2016

Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression

por Aboukameel, Amro, Muqbil, Irfana, Baloglu, Erkan, Senapedis, William, Landesman, Yosef, Argueta, Christian, Kauffman, Michael, Chang, Hua, Kashyap, Trinayan, Shacham, Sharon, Neggers, Jasper E., Daelemans, Dirk, Heath, Elisabeth I., Azmi, Asfar S.
Publicado 2018