Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

por Thomas, Rintu, Srivastava, Shivangi, Katreddy, Rajasekhara Reddy, Sobieski, Jason, Weihua, Zhang
Publicado 2019

Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

por Katreddy, Rajasekhara Reddy, Bollu, Lakshmi Reddy, Su, Fei, Xian, Na, Srivastava, Shivangi, Thomas, Rintu, Dai, Yubing, Wu, Bing, Xu, Yunlu, Rea, Michael A., Briggs, James M., Zhang, Qingyuan, Lu, Xiongbin, Huang, Gangxiong, Weihua, Zhang
Publicado 2018