Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells

por Kaw, Kaveeta, Chattopadhyay, Abhijnan, Guan, Pujun, Chen, Jiyuan, Majumder, Suravi, Duan, Xue-yan, Ma, Shuangtao, Zhang, Chen, Kwartler, Callie S, Milewicz, Dianna M
Publicado 2023

Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast–like Cells Is Driven by an Unfolded Protein Response

por Chattopadhyay, Abhijnan, Kwartler, Callie S., Kaw, Kaveeta, Li, Yanming, Kaw, Anita, Chen, Jiyuan, LeMaire, Scott A., Shen, Ying H., Milewicz, Dianna M.
Publicado 2020

Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation

por Chattopadhyay, Abhijnan, Guan (关蒲骏), Pujun, Majumder, Suravi, Kaw, Kaveeta, Zhou (周桢), Zhen, Zhang, Chen, Prakash, Siddharth K., Kaw, Anita, Buja, L. Maximillian, Kwartler, Callie S., Milewicz, Dianna M.
Publicado 2022

Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle α-actin from the chaperonin-containing TCP1 folding complex

por Chen, Jiyuan, Kaw, Kaveeta, Lu, Hailong, Fagnant, Patricia M., Chattopadhyay, Abhijnan, Duan, Xue Yan, Zhou, Zhen, Ma, Shuangtao, Liu, Zhenan, Huang, Jian, Kamm, Kristine, Stull, James T., Kwartler, Callie S., Trybus, Kathleen M., Milewicz, Dianna M.
Publicado 2021

Augmenting Mitochondrial Respiration in Immature Smooth Muscle Cells with an ACTA2 Pathogenic Variant Mitigates Moyamoya-like Cerebrovascular Disease

por Kaw, Anita, Wu, Ting, Starosolski, Zbigniew, Zhou, Zhen, Pedroza, Albert J., Majumder, Suravi, Duan, Xueyan, Kaw, Kaveeta, Pinelo, Jose E. E., Fischbein, Michael P., Lorenzi, Philip L., Tan, Lin, Martinez, Sara A., Mahmud, Iqbal, Devkota, Laxman, Taegtmeyer, Heinrich, Ghaghada, Ketan B., Marrelli, Sean P., Kwartler, Callie S., Milewicz, Dianna M.
Publicado 2023