Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)

por Noda, Hiroshi, Okazaki, Makoto, Joyashiki, Eri, Tamura, Tatsuya, Kawabe, Yoshiki, Khatri, Ashok, Jueppner, Harald, Potts, John T, Gardella, Thomas J, Shimizu, Masaru
Publicado 2020

Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease

por Ichida, Yasuhiro, Ohtomo, Shuichi, Yamamoto, Tessai, Murao, Naoaki, Tsuboi, Yoshinori, Kawabe, Yoshiki, Segawa, Hiroko, Horiba, Naoshi, Miyamoto, Ken-ichi, Floege, Jürgen
Publicado 2020

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples

por Sugiyama, Masakazu, Kikuchi, Akihiro, Misu, Hirofumi, Igawa, Hirobumi, Ashihara, Motooki, Kushima, Youichi, Honda, Kiyofumi, Suzuki, Yoshiyuki, Kawabe, Yoshiki, Kaneko, Shuichi, Takamura, Toshinari
Publicado 2018

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

por Kitazawa, Takehisa, Esaki, Keiko, Tachibana, Tatsuhiko, Ishii, Shinya, Soeda, Tetsuhiro, Muto, Atsushi, Kawabe, Yoshiki, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro
Publicado 2017

Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

por Noguchi-Sasaki, Mariko, Soeda, Tetsuhiro, Ueyama, Atsunori, Muto, Atsushi, Hirata, Michinori, Kitamura, Hidetomo, Fujimoto-Ouchi, Kaori, Kawabe, Yoshiki, Nogami, Keiji, Shima, Midori, Kitazawa, Takehisa
Publicado 2018

Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism

por Tamura, Tatsuya, Noda, Hiroshi, Joyashiki, Eri, Hoshino, Maiko, Watanabe, Tomoyuki, Kinosaki, Masahiko, Nishimura, Yoshikazu, Esaki, Tohru, Ogawa, Kotaro, Miyake, Taiji, Arai, Shinichi, Shimizu, Masaru, Kitamura, Hidetomo, Sato, Haruhiko, Kawabe, Yoshiki
Publicado 2016

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose

por Fukuzawa, Taku, Fukazawa, Masanori, Ueda, Otoya, Shimada, Hideaki, Kito, Aki, Kakefuda, Mami, Kawase, Yosuke, Wada, Naoko A., Goto, Chisato, Fukushima, Naoshi, Jishage, Kou-ichi, Honda, Kiyofumi, King, George L., Kawabe, Yoshiki
Publicado 2013

Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

por Ueyama, Atsunori, Ban, Nobuhiro, Fukazawa, Masanori, Hirayama, Tohru, Takeda, Minako, Yata, Tatsuo, Muramatsu, Hiroyasu, Hoshino, Masaki, Yamamoto, Marii, Matsuo, Masao, Kawashima, Yuka, Iwase, Tatsuhiko, Kitazawa, Takehisa, Kushima, Youichi, Yamada, Yuichiro, Kawabe, Yoshiki
Publicado 2016

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

por Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Publicado 2018

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

por Kawai, Takahiro, Sun, Bingfa, Yoshino, Hitoshi, Feng, Dan, Suzuki, Yoshiyuki, Fukazawa, Masanori, Nagao, Shunsuke, Wainscott, David B., Showalter, Aaron D., Droz, Brian A., Kobilka, Tong Sun, Coghlan, Matthew P., Willard, Francis S., Kawabe, Yoshiki, Kobilka, Brian K., Sloop, Kyle W.
Publicado 2020

Novel myostatin-specific antibody enhances muscle strength in muscle disease models

por Muramatsu, Hiroyasu, Kuramochi, Taichi, Katada, Hitoshi, Ueyama, Atsunori, Ruike, Yoshinao, Ohmine, Ken, Shida-Kawazoe, Meiri, Miyano-Nishizawa, Rie, Shimizu, Yuichiro, Okuda, Momoko, Hori, Yuji, Hayashi, Madoka, Haraya, Kenta, Ban, Nobuhiro, Nonaka, Tatsuya, Honda, Masaki, Kitamura, Hidetomo, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki, Kawabe, Yoshiki, Nezu, Junichi
Publicado 2021

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

por Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Publicado 2017