Is Buffer a Good Proxy for a Crowded Cell-Like Environment? A Comparative NMR Study of Calmodulin Side-Chain Dynamics in Buffer and E. coli Lysate

por Latham, Michael P., Kay, Lewis E.
Publicado 2012

A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

por Schuetz, Anne K, Kay, Lewis E
Publicado 2016

An Economical Method for Production of (2)H,(13)CH(3)-Threonine for Solution NMR Studies of Large Protein Complexes: Application to the 670 kDa Proteasome

por Velyvis, Algirdas, Ruschak, Amy M., Kay, Lewis E.
Publicado 2012

Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease

por Toyama, Yuki, Harkness, Robert W., Kay, Lewis E.
Publicado 2022

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

por Rosenzweig, Rina, Sekhar, Ashok, Nagesh, Jayashree, Kay, Lewis E
Publicado 2017

Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study

por Vallurupalli, Pramodh, Chakrabarti, Nilmadhab, Pomès, Régis, Kay, Lewis E.
Publicado 2016

Studying Protein-Excited States by Nmr

por Mittermaier, Tony, Mulder, Frans, Dahlquist, Rick, Kay, Lewis E.
Publicado 2002

Exploiting conformational dynamics to modulate the function of designed proteins

por Rennella, Enrico, Sahtoe, Danny D., Baker, David, Kay, Lewis E.
Publicado 2023

Towards autonomous analysis of chemical exchange saturation transfer experiments using deep neural networks

por Karunanithy, Gogulan, Yuwen, Tairan, Kay, Lewis E., Hansen, D. Flemming
Publicado 2022

Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme

por Mondal, Jagannath, Ahalawat, Navjeet, Pandit, Subhendu, Kay, Lewis E., Vallurupalli, Pramodh
Publicado 2018

Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory

por Toyama, Yuki, Rangadurai, Atul Kaushik, Forman-Kay, Julie D., Kay, Lewis E.
Publicado 2022

Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties

por Toyama, Yuki, Rangadurai, Atul Kaushik, Forman-Kay, Julie D., Kay, Lewis E.
Publicado 2022

Structure of a AAA+ unfoldase in the process of unfolding substrate

por Ripstein, Zev A, Huang, Rui, Augustyniak, Rafal, Kay, Lewis E, Rubinstein, John L
Publicado 2017

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

por Sekhar, Ashok, Velyvis, Algirdas, Zoltsman, Guy, Rosenzweig, Rina, Bouvignies, Guillaume, Kay, Lewis E
Publicado 2018

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

por Ripstein, Zev A, Vahidi, Siavash, Houry, Walid A, Rubinstein, John L, Kay, Lewis E
Publicado 2020

Correlating histone acetylation with nucleosome core particle dynamics and function

por Kim, Tae Hun, Nosella, Michael L., Bolik-Coulon, Nicolas, Harkness, Robert W., Huang, Shuya Kate, Kay, Lewis E.
Publicado 2023

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

por Sekhar, Ashok, Rumfeldt, Jessica AO, Broom, Helen R, Doyle, Colleen M, Bouvignies, Guillaume, Meiering, Elizabeth M, Kay, Lewis E
Publicado 2015

NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B

por Zhou, Zheng, Feng, Hanqiao, Hansen, D Flemming, Kato, Hidenori, Luk, Ed, Freedberg, Daron I, Kay, Lewis E, Wu, Carl, Bai, Yawen
Publicado 2008

Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations

por Parupudi, Arun, Chaturvedi, Sumit K., Adão, Regina, Harkness, Robert W., Dragulin-Otto, Sonia, Kay, Lewis E., Esfandiary, Reza, Zhao, Huaying, Schuck, Peter
Publicado 2021

Opening of a cryptic pocket in β-lactamase increases penicillinase activity

por Knoverek, Catherine R., Mallimadugula, Upasana L., Singh, Sukrit, Rennella, Enrico, Frederick, Thomas E., Yuwen, Tairan, Raavicharla, Shreya, Kay, Lewis E., Bowman, Gregory R.
Publicado 2021