Insulin teaches a new lesson in tolerance

por Kay, Thomas W H, Krishnamurthy, Bala, Brodnicki, Thomas C, Mannering, Stuart I
Publicado 2009

Monitoring immunomodulation strategies in type 1 diabetes

por Krishnamurthy, Balasubramanian, Lacorcia, Matthew, Kay, Thomas W. H., Thomas, Helen E., Mannering, Stuart I.
Publicado 2023

Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis

por De George, David J., Ge, Tingting, Krishnamurthy, Balasubramaniam, Kay, Thomas W. H., Thomas, Helen E.
Publicado 2023

Lack of Expression of Gp-130 Makes Pancreatic Beta Cell Lines Unresponsive to the IL-6 Family of Cytokines

por Naselli, Gaetano, Deaizpurua, Henry J., Thomas, Helen E., Johnston, Anne M., Kay, Thomas W. H.
Publicado 2000

IL-17F induces inflammation, dysfunction and cell death in mouse islets

por Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E., Sutherland, Andrew P. R.
Publicado 2020

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

por Niens, Marijke, Grier, Alexandra E., Marron, Michele, Kay, Thomas W.H., Greiner, Dale L., Serreze, David V.
Publicado 2011

IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration

por Scott, Nicholas A., Zhao, Yuxing, Krishnamurthy, Balasubramanian, Mannering, Stuart I., Kay, Thomas W. H., Thomas, Helen E.
Publicado 2018

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

por Pane, Jessica A., Fleming, Fiona E., Graham, Kate L., Thomas, Helen E., Kay, Thomas W. H., Coulson, Barbara S.
Publicado 2016

NF-κB is weakly activated in the NOD mouse model of type 1 diabetes

por Irvin, Allison E., Jhala, Gaurang, Zhao, Yuxing, Blackwell, Timothy S., Krishnamurthy, Balasubramanian, Thomas, Helen E., Kay, Thomas W. H.
Publicado 2018

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

por Jhala, Gaurang, Selck, Claudia, Chee, Jonathan, Kwong, Chun-Ting J., Pappas, Evan G., Thomas, Helen E., Kay, Thomas W.H., Krishnamurthy, Balasubramanian
Publicado 2021

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

por Coppieters, Ken T., Dotta, Francesco, Amirian, Natalie, Campbell, Peter D., Kay, Thomas W.H., Atkinson, Mark A., Roep, Bart O., von Herrath, Matthias G.
Publicado 2012

IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

por Sutherland, Andrew P. R., Graham, Kate L., Papadimitriou, Michelle, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E.
Publicado 2019

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

por Trivedi, Prerak M., Fynch, Stacey, Kennedy, Lucy M., Chee, Jonathan, Krishnamurthy, Balasubramanian, O’Reilly, Lorraine A., Strasser, Andreas, Kay, Thomas W. H., Thomas, Helen E.
Publicado 2019

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

por Krishnamurthy, Balasubramanian, Chee, Jonathan, Jhala, Gaurang, Fynch, Stacey, Graham, Kate L., Santamaria, Pere, Morahan, Grant, Allison, Janette, Izon, David, Thomas, Helen E., Kay, Thomas W.H.
Publicado 2012

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

por McKenzie, Mark D., Jamieson, Emma, Jansen, Elisa S., Scott, Clare L., Huang, David C.S., Bouillet, Philippe, Allison, Janette, Kay, Thomas W.H., Strasser, Andreas, Thomas, Helen E.
Publicado 2010

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizi...

por Bertin-Maghit, Sebastien, Pang, Dimeng, O'Sullivan, Brendan, Best, Shannon, Duggan, Emily, Paul, Sanjoy, Thomas, Helen, Kay, Thomas W.H., Harrison, Leonard C., Steptoe, Raymond, Thomas, Ranjeny
Publicado 2011

Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

por Litwak, Sara A., Wali, Jibran A., Pappas, Evan G., Saadi, Hamdi, Stanley, William J., Varanasi, L. Chitra, Kay, Thomas W. H., Thomas, Helen E., Gurzov, Esteban N.
Publicado 2015

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

por Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E
Publicado 2014

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

por Mannering, Stuart I., Harrison, Leonard C., Williamson, Nicholas A., Morris, Jessica S., Thearle, Daniel J., Jensen, Kent P., Kay, Thomas W.H., Rossjohn, Jamie, Falk, Ben A., Nepom, Gerald T., Purcell, Anthony W.
Publicado 2005

A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy

por Farr, Ryan J., Januszewski, Andrzej S., Joglekar, Mugdha V., Liang, Helena, McAulley, Annie K., Hewitt, Alex W., Thomas, Helen E., Loudovaris, Tom, Kay, Thomas W. H., Jenkins, Alicia, Hardikar, Anandwardhan A.
Publicado 2015