Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

por Ke, Alice Ban, Greupink, Rick, Abduljalil, Khaled
Publicado 2018

PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

por Bolleddula, Jayaprakasam, Ke, Alice, Yang, Hua, Prakash, Chandra
Publicado 2021

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

por Oggianu, Laura, Ke, Alice B., Chetty, Manoranjenni, Picollo, Rossella, Petrucci, Vanessa, Calisti, Fabrizio, Garofolo, Fabio, Tongiani, Serena
Publicado 2020

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

por Rowland Yeo, Karen, Zhang, Mian, Pan, Xian, Ban Ke, Alice, Jones, Hannah M., Wesche, David, Almond, Lisa M.
Publicado 2020

Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations

por Oggianu, Laura, Di Dato, Giorgio, Mangano, Giorgina, Rosignoli, Maria Teresa, McFeely, Savannah, Ke, Alice Ban, Jones, Hannah M., Comandini, Alessandro
Publicado 2022

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

por Kilford, Peter J., Chen, Kuan‐Fu, Crewe, Kim, Gardner, Iain, Hatley, Oliver, Ke, Alice Ban, Neuhoff, Sibylle, Zhang, Mian, Rowland Yeo, Karen
Publicado 2022

Model‐Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor

por Gupta, Neeraj, Hanley, Michael J., Diderichsen, Paul M., Yang, Huyuan, Ke, Alice, Teng, Zhaoyang, Labotka, Richard, Berg, Deborah, Patel, Chirag, Liu, Guohui, van de Velde, Helgi, Venkatakrishnan, Karthik
Publicado 2018

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanc...

por Gupta, Neeraj, Hanley, Michael J., Venkatakrishnan, Karthik, Bessudo, Alberto, Rasco, Drew W., Sharma, Sunil, O'Neil, Bert H., Wang, Bingxia, Liu, Guohui, Ke, Alice, Patel, Chirag, Rowland Yeo, Karen, Xia, Cindy, Zhang, Xiaoquan, Esseltine, Dixie‐Lee, Nemunaitis, John
Publicado 2017