Inhibition of Bruton’s Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer’s Disease

por Keaney, James, Gasser, Julien, Gillet, Gaëlle, Scholz, Diana, Kadiu, Irena
Publicado 2019

Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia

por Gasser, Julien, Gillet, Gaelle, Valadas, Jorge S., Rouvière, Laura, Kotian, Apoorva, Fan, Wenqiang, Keaney, James, Kadiu, Irena
Publicado 2023

Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS

por Clénet, Marie-Laure, Keaney, James, Gillet, Gaëlle, Valadas, Jorge S., Langlois, Julie, Cardenas, Alvaro, Gasser, Julien, Kadiu, Irena
Publicado 2023

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

por Keaney, James, Walsh, Dominic M., O’Malley, Tiernan, Hudson, Natalie, Crosbie, Darragh E., Loftus, Teresa, Sheehan, Florike, McDaid, Jacqueline, Humphries, Marian M., Callanan, John J., Brett, Francesca M., Farrell, Michael A., Humphries, Peter, Campbell, Matthew
Publicado 2015

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

por Srivastava, Prashant K., van Eyll, Jonathan, Godard, Patrice, Mazzuferi, Manuela, Delahaye-Duriez, Andree, Van Steenwinckel, Juliette, Gressens, Pierre, Danis, Benedicte, Vandenplas, Catherine, Foerch, Patrik, Leclercq, Karine, Mairet-Coello, Georges, Cardenas, Alvaro, Vanclef, Frederic, Laaniste, Liisi, Niespodziany, Isabelle, Keaney, James, Gasser, Julien, Gillet, Gaelle, Shkura, Kirill, Chong, Seon-Ah, Behmoaras, Jacques, Kadiu, Irena, Petretto, Enrico, Kaminski, Rafal M., Johnson, Michael R.
Publicado 2018