KCNA2-Related Epileptic Encephalopathy

por Kearney, Jennifer A.
Publicado 2015

Evaluating the interplay between estrous cyclicity and induced seizure susceptibility in Scn2a(K1422E) mice

por Echevarria-Cooper, Dennis M., Kearney, Jennifer A.
Publicado 2023

C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a (+/−) mouse model of Dravet syndrome

por Kang, Seok K., Hawkins, Nicole A., Kearney, Jennifer A.
Publicado 2018

4225 Evaluation of Neurotransmitters in Channelopathy-Related Epilepsy

por Misra, Sunita N, Czech, Theresa M., Kearney, Jennifer A.
Publicado 2020

Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a(K1422E) mice

por Echevarria-Cooper, Dennis M., Hawkins, Nicole A., Kearney, Jennifer A.
Publicado 2023

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

por Hawkins, Nicole A., Lewis, Michael, Hammond, Rebecca S., Doherty, James J., Kearney, Jennifer A.
Publicado 2017

Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

por Calhoun, Jeffrey D., Vanoye, Carlos G., Kok, Fernando, George, Alfred L., Kearney, Jennifer A.
Publicado 2017

K(Na)1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons

por Gertler, Tracy S., Cherian, Suraj, DeKeyser, Jean-Marc, Kearney, Jennifer A., George, Alfred L.
Publicado 2022

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

por Hawkins, Nicole A., Zachwieja, Nicole J., Miller, Alison R., Anderson, Lyndsey L., Kearney, Jennifer A.
Publicado 2016

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

por Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.
Publicado 2017

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

por Hawkins, Nicole A., Anderson, Lyndsey L., Gertler, Tracy S., Laux, Linda, George, Alfred L., Kearney, Jennifer A.
Publicado 2017

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels

por Wang, Dao W., Mistry, Akshitkumar M., Kahlig, Kristopher M., Kearney, Jennifer A., Xiang, Jizhou, George, Alfred L.
Publicado 2010

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome

por Satpute Janve, Vaishali, Anderson, Lyndsey L., Bahceci, Dilara, Hawkins, Nicole A., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2021

Fine mapping and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11

por Kearney, Jennifer A., Copeland-Hardin, Letonia D., Duarte, Samantha, Zachwieja, Nicole A., Eckart-Frank, Isaiah K., Hawkins, Nicole A.
Publicado 2022

Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant

por Kang, Seok Kyu, Hawkins, Nicole A., Echevarria-Cooper, Dennis M., Baker, Erin M., Dixon, Conor J., Speakes, Nathan, Kearney, Jennifer A.
Publicado 2023

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome

por Anderson, Lyndsey L., Bahceci, Dilara A., Hawkins, Nicole A., Everett-Morgan, Declan, Banister, Samuel D., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2023

Gabra2 is a genetic modifier of Dravet syndrome in mice

por Hawkins, Nicole A., Nomura, Toshihiro, Duarte, Samantha, Barse, Levi, Williams, Robert W., Homanics, Gregg E., Mulligan, Megan K., Contractor, Anis, Kearney, Jennifer A.
Publicado 2021

Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant

por Hawkins, Nicole A., Misra, Sunita N, Jurado, Manuel, Kang, Seok Kyu, Vierra, Nicholas C., Nguyen, Kimberly, Wren, Lisa, George, Alfred L., Trimmer, James S., Kearney, Jennifer A.
Publicado 2020

Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span

por Jones, Jana E., Asato, Miya R., Brown, Mesha-Gay, Doss, Julia L., Felton, Elizabeth A., Kearney, Jennifer A., Talos, Delia, Dacks, Penny A., Whittemore, Vicky, Poduri, Annapurna
Publicado 2020

Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice

por Hawkins, Nicole A., Jurado, Manuel, Thaxton, Tyler T., Duarte, Samantha E., Barse, Levi, Tatsukawa, Tetsuya, Yamakawa, Kazuhiro, Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Abrahams, Brett S., During, Matthew J., Kearney, Jennifer A.
Publicado 2021