Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour...

por Moroz, Veronica, Wilson, Jayne S, Kearns, Pamela, Wheatley, Keith
Publicado 2014

Analysis of Global Pediatric Cancer Research and Publications

por Syrimi, Eleni, Lewison, Grant, Sullivan, Richard, Kearns, Pamela
Publicado 2020

Challenges of Clinical Trial Design for Targeted Agents Against Pediatric Leukemias

por Mussai, Francis Jay, Yap, Christina, Mitchell, Christopher, Kearns, Pamela
Publicado 2015

Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP...

por Weston, Victoria J., Wei, Wenbin, Stankovic, Tatjana, Kearns, Pamela
Publicado 2018

Sequential Treatment with Cytarabine and Decitabine Has an Increased Anti-Leukemia Effect Compared to Cytarabine Alone in Xenograft Models of Childhood Acute Myeloid Leukemia

por Leonard, Sarah M., Perry, Tracey, Woodman, Ciarán B., Kearns, Pamela
Publicado 2014

The paediatric hepatic international tumour trial (PHITT): clinical trial design in rare disease

por Moroz, Veronica, Morland, Bruce, Tiao, Gregory, Hiyama, Eiso, Kearns, Pamela, Wheatley, Keith
Publicado 2015

Does ‘mapping’ the evidence usefully inform the research question prioritisation process in systematic reviews?

por Main, Caroline, Wilson, Jayne, English, Martin, Kearns, Pamela, Phillips, Bob, Pizer, Barry, Wilne, Sophie, Wheatley, Keith
Publicado 2015

The impact of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with central nervous system (CNS) tumours: protocol for a...

por Main, Caroline, Stevens, Simon P., Bailey, Simon, Phillips, Robert, Pizer, Barry, Wheatley, Keith, Kearns, Pamela R., English, Martin, Wilne, Sophie, Wilson, Jayne S.
Publicado 2016

The role of high-dose myeloablative chemotherapy with haematopoietic stem cell transplantation (HSCT) in children with central nervous system (CNS) tumours: protocol for a systemat...

por Main, Caroline, Wilson, Jayne S., Stevens, Simon P., Houlton, Aimee E., English, Martin, Kearns, Pamela R., Phillips, Bob, Pizer, Barry, Wilne, Sophie, Wheatley, Keith
Publicado 2015

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas

por Gatz, Susanne A., Aladowicz, Ewa, Casanova, Michela, Chisholm, Julia C., Kearns, Pamela R., Fulda, Simone, Geoerger, Birgit, Schäfer, Beat W., Shipley, Janet M.
Publicado 2019

What could be a cancer mission objective if we join our forces in the fight against cancer?

por Philip, Thierry, Karjalainen, Sakari, De Lorenzo, Francesco, Apostolidis, Kathi, Lombardo, Claudio, Nilbert, Mef, Lacombe, Denis, Poortmans, Philip, Albreht, Tit, Kearns, Pamela, Vassal, Gilles
Publicado 2019

Changing incentives to ACCELERATE drug development for paediatric cancer

por de Rojas, Teresa, Kearns, Pamela, Blanc, Patricia, Skolnik, Jeffrey, Fox, Elizabeth, Knox, Leona, Rousseau, Raphael, Doz, François, Bird, Nick, Pearson, Andrew J., Vassal, Gilles
Publicado 2023

Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model

por Pais, Helio, Ruggero, Katia, Zhang, Jing, Al-Assar, Osama, Bery, Nicolas, Bhuller, Ravneet, Weston, Victoria, Kearns, Pamela R., Mecucci, Cristina, Miller, Ami, Rabbitts, Terence H.
Publicado 2019

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

por Mussai, Francis, Wheat, Rachel, Sarrou, Evgenia, Booth, Sarah, Stavrou, Victoria, Fultang, Livingstone, Perry, Tracey, Kearns, Pamela, Cheng, Paul, Keeshan, Karen, Craddock, Charles, De Santo, Carmela
Publicado 2019

Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study proto...

por Menne, Tobias, Slade, Daniel, Savage, Joshua, Johnson, Sarah, Irving, Julie, Kearns, Pamela, Plummer, Ruth, Shenton, Geoff, Veal, Gareth J, Vormoor, Britta, Vormoor, Josef, Billingham, Lucinda
Publicado 2022

The utility of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with low-grade central nervous system (CNS) tumours: a s...

por Stevens, Simon P., Main, Caroline, Bailey, Simon, Pizer, Barry, English, Martin, Phillips, Robert, Peet, Andrew, Avula, Shivaram, Wilne, Sophie, Wheatley, Keith, Kearns, Pamela R., Wilson, Jayne S.
Publicado 2018

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

por De Santo, Carmela, Booth, Sarah, Vardon, Ashley, Cousins, Antony, Tubb, Vanessa, Perry, Tracey, Noyvert, Boris, Beggs, Andrew, Ng, Margaret, Halsey, Christina, Kearns, Pamela, Cheng, Paul, Mussai, Francis
Publicado 2017

Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort...

por Nohtani, Mahdi, Vrzalikova, Katerina, Ibrahim, Maha, Powell, Judith E., Fennell, Éanna, Morgan, Susan, Grundy, Richard, McCarthy, Keith, Dewberry, Sarah, Bouchal, Jan, Bouchalova, Katerina, Kearns, Pamela, Murray, Paul G.
Publicado 2022

The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours: protocol for a systematic review

por Main, Caroline, Dandapani, Madhumita, Pritchard, Mark, Dodds, Rachel, Stevens, Simon P., Thorp, Nicky, Taylor, Roger E., Wheatley, Keith, Pizer, Barry, Morrall, Matthew, Phillips, Robert, English, Martin, Kearns, Pamela R., Wilne, Sophie, Wilson, Jayne S.
Publicado 2016

Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective

por Blagden, Sarah P., Yu, Ly-Mee, Ellis, Stephanie, Hughes, Helen, Shaaban, Abeer, Fennelly-Barnwell, Jonathan, Lythgoe, Mark P., Cooper, Alison M., Maignen, Francois M., Buckland, Sean W., Kearns, Pamela R., Brown, Louise C.
Publicado 2022