Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic

por Balakrishnan, Kumudha, Fu, Min, Onida, Francesco, Wierda, William G., Keating, Michael J., Gandhi, Varsha
Publicado 2016

Idelalisib and bendamustine combination is synergistic and increases DNA damage response in chronic lymphocytic leukemia cells

por Modi, Prexy, Balakrishnan, Kumudha, Yang, Qingshan, Wierda, William G., Keating, Michael J., Gandhi, Varsha
Publicado 2017

Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism

por Liu, Jinyun, Chen, Gang, Pelicano, Helene, Liao, Jianwei, Huang, Jie, Feng, Li, Keating, Michael J., Huang, Peng
Publicado 2016

PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells

por Cervantes-Gomez, Fabiola, Stellrecht, Christine M., Ayres, Mary L., Keating, Michael J., Wierda, William G., Gandhi, Varsha
Publicado 2019

Signal Transducer and Activator of Transcription–3 Induces MicroRNA-155 Expression in Chronic Lymphocytic Leukemia

por Li, Ping, Grgurevic, Srdana, Liu, Zhiming, Harris, David, Rozovski, Uri, Calin, George A., Keating, Michael J., Estrov, Zeev
Publicado 2013

Del(20q) in patients with chronic lymphocytic leukemia: A therapy-related abnormality involving lymphoid or myeloid cells

por Yin, C. Cameron, Tang, Guilin, Lu, Gary, Feng, Xiaoli, Keating, Michael J., Medeiros, L. Jeffrey, Abruzzo, Lynne V.
Publicado 2015

Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic leukemia cells

por Chen, Rong, Chen, Yuling, Xiong, Ping, Zheleva, Daniella, Blake, David, Keating, Michael J., Wierda, William G., Plunkett, William
Publicado 2022

Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells

por Vangapandu, Hima V., Alston, Brandon, Morse, Joshua, Ayres, Mary L., Wierda, William G., Keating, Michael J., Marszalek, Joseph R., Gandhi, Varsha
Publicado 2018

The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells()()

por Vangapandu, Hima V., Ayres, Mary L., Bristow, Christopher A., Wierda, William G., Keating, Michael J., Balakrishnan, Kumudha, Stellrecht, Christine M., Gandhi, Varsha
Publicado 2017

Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression

por Admirand, Joan H., Knoblock, Ronald J., Coombes, Kevin R., Tam, Constantine, Schlette, Ellen J., Keating, Michael J., Luthra, Rajyalakshmi, Medeiros, L. Jeffrey, Abruzzo, Lynne V.
Publicado 2010

Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways

por Abruzzo, Lynne V., Herling, Carmen D., Calin, George A., Oakes, Christopher, Barron, Lynn L., Banks, Haley E., Katju, Vikram, Keating, Michael J., Coombes, Kevin R.
Publicado 2018

STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells

por Rozovski, Uri, Harris, David M., Li, Ping, Liu, Zhiming, Jain, Preetesh, Ferrajoli, Alessandra, Burger, Jan, Thompson, Phillip, Jain, Nitin, Wierda, William, Keating, Michael J., Estrov, Zeev
Publicado 2018

STAT3 is constitutively acetylated on lysine 685 residues in chronic lymphocytic leukemia cells

por Rozovski, Uri, Harris, David M., Li, Ping, Liu, Zhiming, Jain, Preetesh, Ferrajoli, Alessandra, Burger, Jan, Thompson, Phillip, Jain, Nitin, Wierda, William, Keating, Michael J., Estrov, Zeev
Publicado 2018

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

por Pelicano, Hélène, Xu, Rui-hua, Du, Min, Feng, Li, Sasaki, Ryohei, Carew, Jennifer S., Hu, Yumin, Ramdas, Latha, Hu, Limei, Keating, Michael J., Zhang, Wei, Plunkett, William, Huang, Peng
Publicado 2006

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukemia

por Zhang, Wan, Trachootham, Dunyaporn, Liu, Jinyun, Chen, Gang, Pelicano, Helene, Garcia-Prieto, Celia, Lu, Weiqin, Burger, Jan A, Croce, Carlo M, Plunkett, William, Keating, Michael J, Huang, Peng
Publicado 2012

Elimination of Chronic Lymphocytic Leukemia Cells in Stromal Microenvironment by Targeting CPT with an Anti-Angina Drug Perhexiline

por Liu, Pan-pan, Liu, Jinyun, Jiang, Wen-qi, Carew, Jennifer S., Ogasawara, Marcia A., Pelicano, Hélène, Croce, Carlo M., Estrov, Zeev, Xu, Rui-hua, Keating, Michael J., Huang, Peng
Publicado 2016

The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action

por Chen, Rong, Tsai, Jennifer, Thompson, Philip A., Chen, Yuling, Xiong, Ping, Liu, Chaomei, Burrows, Francis, Sivina, Mariela, Burger, Jan A., Keating, Michael J., Wierda, William G., Plunkett, William
Publicado 2021

The BET Inhibitor GS-5829 Targets Chronic Lymphocytic Leukemia Cells and Their Supportive Microenvironment

por Kim, Ekaterina, ten Hacken, Elisa, Sivina, Mariela, Clarke, Astrid, Thompson, Philip A., Jain, Nitin, Ferrajoli, Alessandra, Estrov, Zeev, Keating, Michael J., Wierda, William G., Bhalla, Kapil N., Burger, Jan A.
Publicado 2019

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

por Lu, Weiqin, Hu, Yumin, Chen, Gang, Chen, Zhao, Zhang, Hui, Wang, Feng, Feng, Li, Pelicano, Helene, Wang, Hua, Keating, Michael J., Liu, Jinsong, McKeehan, Wallace, Wang, Huamin, Luo, Yongde, Huang, Peng
Publicado 2012

Correction: Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

por Lu, Weiqin, Hu, Yumin, Chen, Gang, Chen, Zhao, Zhang, Hui, Wang, Feng, Feng, Li, Pelicano, Helene, Wang, Hua, Keating, Michael J., Liu, Jinsong, McKeehan, Wallace, Wang, Huamin, Luo, Yongde, Huang, Peng
Publicado 2017