A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase

por Gay, Darren C., Spear, Philip J., Keatinge-Clay, Adrian T.
Publicado 2014

An in vitro platform for engineering and harnessing modular polyketide synthases

por Miyazawa, Takeshi, Hirsch, Melissa, Zhang, Zhicheng, Keatinge-Clay, Adrian T.
Publicado 2020

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

por Garg, Ashish, Xie, Xinqiang, Keatinge-Clay, Adrian, Khosla, Chaitan, Cane, David E.
Publicado 2014

Divergence of multimodular polyketide synthases revealed by a didomain structure

por Zheng, Jianting, Gay, Darren C., Demeler, Borries, White, Mark A., Keatinge-Clay, Adrian T.
Publicado 2012

Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates

por Stevens, D. Cole, Wagner, Drew T., Manion, Hannah R., Alexander, Bradley K., Keatinge-Clay, Adrian T.
Publicado 2016

Structural Studies of the Spinosyn Forosaminyltransferase, SpnP

por Isiorho, Eta A., Jeon, Byung-Sun, Kim, Nam Ho, Liu, Hung-wen, Keatinge-Clay, Adrian T.
Publicado 2014

The Structure of SpnF, a Standalone Enzyme that Catalyzes [4+2] Cycloaddition

por Fage, Christopher D., Isiorho, Eta A., Liu, Yungnan, Wagner, Drew T., Liu, Hung-wen, Keatinge-Clay, Adrian T.
Publicado 2015

Antimicrobial Peptide Resistance of Vibrio cholerae Results from an LPS Modification Pathway Related to Nonribosomal Peptide Synthetases

por Henderson, Jeremy C., Fage, Christopher D., Cannon, Joe R., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T., Trent, M. Stephen
Publicado 2014

Assessing and harnessing updated polyketide synthase modules through combinatorial engineering

por Ray, Katherine A., Lutgens, Joshua D., Bista, Ramesh, Zhang, Jie, Desai, Ronak R., Hirsch, Melissa, Miyazawa, Takeshi, Cordova, Antonio, Keatinge-Clay, Adrian T.
Publicado 2023

Generalized bacterial genome editing using mobile group II introns and Cre-lox

por Enyeart, Peter J, Chirieleison, Steven M, Dao, Mai N, Perutka, Jiri, Quandt, Erik M, Yao, Jun, Whitt, Jacob T, Keatinge-Clay, Adrian T, Lambowitz, Alan M, Ellington, Andrew D
Publicado 2013