Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway

por Liu, Enze, Becker, Nathan, Sudha, Parvathi, Dong, Chuanpeng, Liu, Yunlong, Keats, Jonathan, Morgan, Gareth, Walker, Brian A.
Publicado 2023

Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma Cells

por Suzuki, Erika, Demo, Susan, Deu, Edgar, Keats, Jonathan, Arastu-Kapur, Shirin, Bergsagel, P. Leif, Bennett, Mark K., Kirk, Christopher J.
Publicado 2011

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma

por Cheng, Javelin C, McBrayer, Samuel K, Coarfa, Cristian, Dalva-Aydemir, Sevim, Gunaratne, Preethi H, Carpten, John D, Keats, Jonathan K, Rosen, Steven T, Shanmugam, Mala
Publicado 2013

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21(Cip1)

por Mei, Anna Huo-Chang, Tung, Kaity, Han, Jessie, Perumal, Deepak, Laganà, Alessandro, Keats, Jonathan, Auclair, Daniel, Chari, Ajai, Jagannath, Sundar, Parekh, Samir, Cho, Hearn Jay
Publicado 2020

Promiscuous Rearrangements of the MYC Locus Hijack Enhancers and Super-Enhancers to Dysregulate MYC Expression in Multiple Myeloma

por Affer, Maurizio, Chesi, Marta, Chen, Wei-Dong G., Keats, Jonathan J., Demchenko, Yulia N., Roschke, Anna V., Van Wier, Scott, Fonseca, Rafael, Bergsagel, P. Leif, Kuehl, W. Michael
Publicado 2014

Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing

por Chow, Signy, Kis, Olena, Mulder, David T, Danesh, Arnavaz, Bruce, Jeff, Wang, Ting Ting, Reece, Donna, Bhalis, Nizar, Neri, Paola, Sabatini, Peter JB, Keats, Jonathan, Trudel, Suzanne, Pugh, Trevor J
Publicado 2022

Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities

por Braggio, Esteban, Dogan, Ahmet, Keats, Jonathan J, Chng, Wee J, Huang, Gaofeng, Matthews, Julie M, Maurer, Matthew J, Law, Mark E, Bosler, David S, Barrett, Michael, Lossos, Izidore S, Witzig, Thomas, Fonseca, Rafael
Publicado 2012

Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases

por Manojlovic, Zarko, Christofferson, Austin, Liang, Winnie S., Aldrich, Jessica, Washington, Megan, Wong, Shukmei, Rohrer, Daniel, Jewell, Scott, Kittles, Rick A., Derome, Mary, Auclair, Daniel, Craig, David Wesley, Keats, Jonathan, Carpten, John D.
Publicado 2017

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

por Longo, Joseph, Smirnov, Petr, Li, Zhihua, Branchard, Emily, van Leeuwen, Jenna E., Licht, Jonathan D., Haibe-Kains, Benjamin, Andrews, David W., Keats, Jonathan J., Pugh, Trevor J., Trudel, Suzanne, Penn, Linda Z.
Publicado 2020

CNV Radar: an improved method for somatic copy number alteration characterization in oncology

por Soong, David, Stratford, Jeran, Avet-Loiseau, Herve, Bahlis, Nizar, Davies, Faith, Dispenzieri, Angela, Sasser, A. Kate, Schecter, Jordan M., Qi, Ming, Brown, Chad, Jones, Wendell, Keats, Jonathan J., Auclair, Daniel, Chiu, Christopher, Powers, Jason, Schaffer, Michael
Publicado 2020

The CCND1 c.870G risk allele is enriched in individuals of African ancestry with plasma cell dyscrasias

por Baughn, Linda B., Li, Zhuo, Pearce, Kathryn, Vachon, Celine M., Polley, Mei-Yin, Keats, Jonathan, Elhaik, Eran, Baird, Michael, Therneau, Terry, Cerhan, James R., Bergsagel, P. Leif, Dispenzieri, Angela, Rajkumar, S. Vincent, Asmann, Yan W., Kumar, Shaji
Publicado 2020

Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications

por Bhalla, Sherry, Melnekoff, David T., Aleman, Adolfo, Leshchenko, Violetta, Restrepo, Paula, Keats, Jonathan, Onel, Kenan, Sawyer, Jeffrey R., Madduri, Deepu, Richter, Joshua, Richard, Shambavi, Chari, Ajai, Cho, Hearn Jay, Dudley, Joel T., Jagannath, Sundar, Laganà, Alessandro, Parekh, Samir
Publicado 2021

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition

por Mohan, Pooja, Castellsague, Joan, Jiang, Jihong, Allen, Kristi, Chen, Helen, Nemirovsky, Oksana, Spyra, Melanie, Hu, Kaiji, Kluwe, Lan, Pujana, Miguel Angel, Villanueva, Alberto, Mautner, Victor F., Keats, Jonathan J., Dunn, Sandra E., Lazaro, Conxi, Maxwell, Christopher A.
Publicado 2013

Structural variants shape the genomic landscape and clinical outcome of multiple myeloma

por Ashby, Cody, Boyle, Eileen M., Bauer, Michael A., Mikulasova, Aneta, Wardell, Christopher P., Williams, Louis, Siegel, Ariel, Blaney, Patrick, Braunstein, Marc, Kaminetsky, David, Keats, Jonathan, Maura, Francesco, Landgren, Ola, Walker, Brian A., Davies, Faith E., Morgan, Gareth J.
Publicado 2022

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

por Barwick, Benjamin G., Neri, Paola, Bahlis, Nizar J., Nooka, Ajay K., Dhodapkar, Madhav V., Jaye, David L., Hofmeister, Craig C., Kaufman, Jonathan L., Gupta, Vikas A., Auclair, Daniel, Keats, Jonathan J., Lonial, Sagar, Vertino, Paula M., Boise, Lawrence H.
Publicado 2019

A method to reduce ancestry related germline false positives in tumor only somatic variant calling

por Halperin, Rebecca F., Carpten, John D., Manojlovic, Zarko, Aldrich, Jessica, Keats, Jonathan, Byron, Sara, Liang, Winnie S., Russell, Megan, Enriquez, Daniel, Claasen, Ana, Cherni, Irene, Awuah, Baffour, Oppong, Joseph, Wicha, Max S., Newman, Lisa A., Jaigge, Evelyn, Kim, Seungchan, Craig, David W.
Publicado 2017

Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

por Gupta, Vikas A., Barwick, Benjamin G., Matulis, Shannon M., Shirasaki, Ryosuke, Jaye, David L., Keats, Jonathan J., Oberlton, Benjamin, Joseph, Nisha S., Hofmeister, Craig C., Heffner, Leonard T., Dhodapkar, Madhav V., Nooka, Ajay K., Lonial, Sagar, Mitsiades, Constantine S., Kaufman, Jonathan L., Boise, Lawrence H.
Publicado 2021

Long Intergenic Non-Coding RNAs have an Independent Impact on Survival in Multiple Myeloma

por Samur, Mehmet Kemal, Minvielle, Stephane, Gulla, Annamaria, Fulciniti, Mariateresa, Cleynen, Alice, Samur, Anil Aktas, Szalat, Raphael, Shammas, Masood, Magrangeas, Florence, Tai, Yu-Tzu, Auclair, Daniel, Keats, Jonathan, Richardson, Paul, Attal, Michel, Moreau, Philippe, Anderson, Kenneth C., Parmigiani, Giovanni, Avet-Loiseau, Hervé, Munshi, Nikhil C.
Publicado 2018

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

por Mikulasova, Aneta, Ashby, Cody, Tytarenko, Ruslana G., Qu, Pingping, Rosenthal, Adam, Dent, Judith A., Ryan, Katie R., Bauer, Michael A., Wardell, Christopher P., Hoering, Antje, Mavrommatis, Konstantinos, Trotter, Matthew, Deshpande, Shayu, Yaccoby, Shmuel, Tian, Erming, Keats, Jonathan, Auclair, Daniel, Jackson, Graham H., Davies, Faith E., Thakurta, Anjan, Morgan, Gareth J., Walker, Brian A.
Publicado 2020

c‐MYC expression and maturity phenotypes are associated with outcome benefit from addition of ixazomib to lenalidomide‐dexamethasone in myeloma

por Di Bacco, Alessandra, Bahlis, Nizar J., Munshi, Nikhil C., Avet‐Loiseau, Hervé, Masszi, Tamás, Viterbo, Luísa, Pour, Ludek, Ganly, Peter, Cavo, Michele, Langer, Christian, Kumar, Shaji K., Rajkumar, S. Vincent, Keats, Jonathan J., Berg, Deborah, Lin, Jianchang, Li, Bin, Badola, Sunita, Shen, Lei, Zhang, Jacob, Esseltine, Dixie‐Lee, Luptakova, Katarina, van de Velde, Helgi, Richardson, Paul G., Moreau, Philippe
Publicado 2020