Journey to the center of the protein: allostery from multitemperature multiconformer X-ray crystallography

por Keedy, Daniel A.
Publicado 2019

Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B

por Sharma, Shivani, Ebrahim, Ali, Keedy, Daniel A.
Publicado 2023

Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS

por Woods, Virgil A., Abzalimov, Rinat R., Keedy, Daniel A.
Publicado 2023

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit

por Keedy, Daniel A., Fraser, James S., van den Bedem, Henry
Publicado 2015

Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase

por Guerrero, Liliana, Ebrahim, Ali, Riley, Blake T., Kim, Minyoung, Huang, Qingqiu, Finke, Aaron D., Keedy, Daniel A.
Publicado 2023

Autofix for backward-fit sidechains: using MolProbity and real-space refinement to put misfits in their place

por Headd, Jeffrey J., Immormino, Robert M., Keedy, Daniel A., Emsley, Paul, Richardson, David C., Richardson, Jane S.
Publicado 2008

The Role of Local Backrub Motions in Evolved and Designed Mutations

por Keedy, Daniel A., Georgiev, Ivelin, Triplett, Edward B., Donald, Bruce R., Richardson, David C., Richardson, Jane S.
Publicado 2012

Conformational variation of proteins at room temperature is not dominated by radiation damage

por Russi, Silvia, González, Ana, Kenner, Lillian R., Keedy, Daniel A., Fraser, James S., van den Bedem, Henry
Publicado 2017

The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M(pro))

por Ebrahim, Ali, Riley, Blake T., Kumaran, Desigan, Andi, Babak, Fuchs, Martin R., McSweeney, Sean, Keedy, Daniel A.
Publicado 2021

The tem­per­ature-dependent conformational ensemble of SARS-CoV-2 main protease (M(pro))

por Ebrahim, Ali, Riley, Blake T., Kumaran, Desigan, Andi, Babak, Fuchs, Martin R., McSweeney, Sean, Keedy, Daniel A.
Publicado 2022

Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM

por Wankowicz, Stephanie A., Ravikumar, Ashraya, Sharma, Shivani, Riley, Blake T., Raju, Akshay, Hogan, Daniel W., van den Bedem, Henry, Keedy, Daniel A., Fraser, James S.
Publicado 2023

MolProbity: all-atom structure validation for macromolecular crystallography

por Chen, Vincent B., Arendall, W. Bryan, Headd, Jeffrey J., Keedy, Daniel A., Immormino, Robert M., Kapral, Gary J., Murray, Laura W., Richardson, Jane S., Richardson, David C.
Publicado 2010

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

por Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S
Publicado 2018

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

por Skaist Mehlman, Tamar, Biel, Justin T, Azeem, Syeda Maryam, Nelson, Elliot R, Hossain, Sakib, Dunnett, Louise, Paterson, Neil G, Douangamath, Alice, Talon, Romain, Axford, Danny, Orins, Helen, von Delft, Frank, Keedy, Daniel A
Publicado 2023

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

por Keedy, Daniel A, Kenner, Lillian R, Warkentin, Matthew, Woldeyes, Rahel A, Hopkins, Jesse B, Thompson, Michael C, Brewster, Aaron S, Van Benschoten, Andrew H, Baxter, Elizabeth L, Uervirojnangkoorn, Monarin, McPhillips, Scott E, Song, Jinhu, Alonso-Mori, Roberto, Holton, James M, Weis, William I, Brunger, Axel T, Soltis, S Michael, Lemke, Henrik, Gonzalez, Ana, Sauter, Nicholas K, Cohen, Aina E, van den Bedem, Henry, Thorne, Robert E, Fraser, James S
Publicado 2015