Nonsense Suppression as an Approach to Treat Lysosomal Storage Diseases

por Keeling, Kim M.
Publicado 2016

Finding sense in the context

por Keeling, Kim M, Bedwell, David M
Publicado 2020

RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay

por Siddiqui, Amna, Saxena, Arpit, Echols, Joshua, Havasi, Viktoria, Fu, Lianwu, Keeling, Kim M.
Publicado 2023

A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases

por Echols, Josh, Siddiqui, Amna, Dai, Yanying, Havasi, Viktoria, Sun, Richard, Kaczmarczyk, Aneta, Keeling, Kim M.
Publicado 2020

Ataluren suppresses a premature termination codon in an MPS I-H mouse

por Wang, Dan, Xue, Xiaojiao, Gunn, Gwen, Du, Ming, Siddiqui, Amna, Weetall, Marla, Keeling, Kim M.
Publicado 2022

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

por Keeling, Kim M., Wang, Dan, Dai, Yanying, Murugesan, Srinivasan, Chenna, Balachandra, Clark, Jeremy, Belakhov, Valery, Kandasamy, Jeyakumar, Velu, Sadanandan E., Baasov, Timor, Bedwell, David M.
Publicado 2013

The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators

por Chen, Jianguo, Thrasher, Kari, Fu, Lianwu, Wang, Wei, Aghamohammadzadeh, Soheil, Wen, Hui, Tang, Liping, Keeling, Kim M., Falk Libby, Emily, Bedwell, David M., Rowe, Steven M.
Publicado 2023

Mutation-Directed Therapeutics for Neurofibromatosis Type I

por Leier, Andre, Bedwell, David M., Chen, Ann T., Dickson, George, Keeling, Kim M., Kesterson, Robert A., Korf, Bruce R., Marquez Lago, Tatiana T., Müller, Ulrich F., Popplewell, Linda, Zhou, Jiangbing, Wallis, Deeann
Publicado 2020

Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome)

por Siddiqui, Amna, Dundar, Halil, Sharma, Jyoti, Kaczmarczyk, Aneta, Echols, Josh, Dai, Yanying, Sun, Chuanxi Richard, Du, Ming, Liu, Zhong, Zhao, Rui, Wood, Tim, Sanders, Shalisa, Rasmussen, Lynn, Bostwick, James Robert, Augelli-Szafran, Corinne, Suto, Mark, Rowe, Steven M., Bedwell, David M., Keeling, Kim M.
Publicado 2023

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

por Sharma, Jyoti, Du, Ming, Wong, Eric, Mutyam, Venkateshwar, Li, Yao, Chen, Jianguo, Wangen, Jamie, Thrasher, Kari, Fu, Lianwu, Peng, Ning, Tang, Liping, Liu, Kaimao, Mathew, Bini, Bostwick, Robert J., Augelli-Szafran, Corinne E., Bihler, Hermann, Liang, Feng, Mahiou, Jerome, Saltz, Josef, Rab, Andras, Hong, Jeong, Sorscher, Eric J., Mendenhall, Eric M., Coppola, Candice J., Keeling, Kim M., Green, Rachel, Mense, Martin, Suto, Mark J., Rowe, Steven M., Bedwell, David M.
Publicado 2021