New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D(2) receptor regulation and signaling

por Mann, Anika, Keen, Alastair C., Mark, Hanka, Dasgupta, Pooja, Javitch, Jonathan A., Canals, Meritxell, Schulz, Stefan, Robert Lane, J.
Publicado 2021

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

por Roberts, Maxine J., May, Lauren T., Keen, Alastair C., Liu, Bonan, Lam, Terrance, Charlton, Steven J., Rosethorne, Elizabeth M., Halls, Michelle L.
Publicado 2021

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

por Lane, J Robert, Abramyan, Ara M, Adhikari, Pramisha, Keen, Alastair C, Lee, Kuo-Hao, Sanchez, Julie, Verma, Ravi Kumar, Lim, Herman D, Yano, Hideaki, Javitch, Jonathan A, Shi, Lei
Publicado 2020

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα(z)

por Keen, Alastair C., Pedersen, Maria Hauge, Lemel, Laura, Scott, Daniel J., Canals, Meritxell, Littler, Dene R., Beddoe, Travis, Ono, Yuki, Shi, Lei, Inoue, Asuka, Javitch, Jonathan A., Lane, J. Robert
Publicado 2022

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

por Chang, Yong-Gang, Lupton, Christopher J., Bayly-Jones, Charles, Keen, Alastair C., D’Andrea, Laura, Lucato, Christina M., Steele, Joel R., Venugopal, Hari, Schittenhelm, Ralf B., Whisstock, James C., Halls, Michelle L., Ellisdon, Andrew M.
Publicado 2022